Radiologic Findings of a Rare Subtype of Invasive Breast Cancer with Poor Prognosis: Metaplastic Carcinoma of the Breast
Radiologic Findings of a Rare Subtype of Invasive Breast Cancer with Poor Prognosis: Metaplastic Carcinoma of the Breast
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DOI：
10.2174/1573405614666180813120227
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发表时间：
2019-01-01
影响因子：
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通讯作者：
Aribas, Bilgin Kadri
中科院分区：
文献类型：
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作者：
Aydin, Hale;Guner, Bahar;Aribas, Bilgin Kadri
背景和目标：本研究的目的是评估乳腺化生carcinoma.Methods的钼靶摄影，超声和MRI表现：在这项回顾性研究中，我们分析了9600例浸润性乳腺癌患者的医疗档案。本研究包括65例患者的临床资料、组织病理学和放射学检查结果。回顾性审查了所有现有的放射学图像和医学报告。结果：MPBC最常见的X线表现为圆形、边缘微分叶状、高密度肿块，其中MG 33例，US 58例，MRI 7例。钙化伴或不伴肿块并不常见。最常见的声像图表现为肿块呈圆形，部分角缘不清，回声低而不均匀，后方无特征性肿块。所有病变在磁共振成像上表现为肿块而不是非肿块增强。结论：化生性乳腺癌是一种少见的低分化浸润性乳腺癌。有趣的是，这些侵袭性肿瘤在成像方法上显示出良性或中度恶性特征。MPBC的这种外观可能会导致其被误诊为良性乳腺病变，特别是在年轻女性中。在可触及的巨大乳腺肿块的鉴别诊断中，应牢记MPBC。因此，短时间随访和/或包括乳腺MRI在内的多模态成像研究对MPBC的诊断非常重要。
Background and Objectives: The purpose of this study was to evaluate the mammographic, sonographic and MRI findings of metaplastic breast carcinoma.Methods: In this retrospective review study, we analyzed the medical files of 9600 patients who were treated for invasive breast cancers. Clinical information, histopathologic and radiologic findings of 65 patients were included in this study. All existing radiologic images and medical reports were reviewed retrospectively. Thirty-three patients had MG, 58 patients had US and 7 patients had MRI imaging results.Results: Mammographically, the most frequent presentations of MPBC were round shape, microlobulated margin and high density masses. Calcifications with or without masses were not a frequent finding. The most common sonographic findings were round shape, partially indistinct angular margin, hypoechoic and heterogeneous echo patterns and no posterior feature masses. All lesions were presented as masses rather than non-mass enhancements on magnetic resonance imaging. Features of masses had more malignant feature on MRI than other modalities in all 7 patients.Conclusion: Metaplastic breast carcinoma is one of the rarest poorly differentiated invasive breast carcinomas. Interestingly, these aggressive tumors demonstrate benign or moderately malign features on imaging methods. This appearance of MPBC can cause it to be misdiagnosed as a benign breast lesion especially in young women. MPBC should be kept in mind in the differential diagnosis of large palpable breast masses. Therefore, follow-up at short intervals and/or multimodality imaging studies which include breast MRI are important for the diagnosis of MPBC.