Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain
Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain
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DOI：
10.1093/toxsci/kfl139
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发表时间：
2007-01-01
影响因子：
3.8
通讯作者：
Aschner, Michael
中科院分区：
文献类型：
--
作者：
Garcia, Stephanie J.;Gellein, Kristin;Aschner, Michael
锰（Mn）神经毒性可导致类似于帕金森病的心理和神经障碍，包括锥体外系运动系统缺陷和行为改变。铁（Fe）缺乏症是世界上最普遍的营养失调症之一，影响约20亿人，特别是孕妇和哺乳期妇女、婴儿、幼儿和青少年。即使在环境或饮食中没有过量锰的情况下，铁缺乏也可以增强脑锰的积累。为了评估发育过程中膳食铁缺乏和过量Mn的神经化学相互作用，新生大鼠在哺乳期（出生后第4-21天[PN]）暴露于对照饮食、低铁饮食（ID）或通过母乳补充Mn的低铁饮食（IDMn）。在PN 21幼崽，ID和IDMn饮食产生的变化，血液参数的特点，铁缺乏症：血红蛋白（Hb）和血浆铁，增加血浆转铁蛋白（Tf），和总铁结合力（TIBC）。给药ID和IDMn母鼠在整个哺乳期内的Hb也降低，ID母鼠在PN 21时血浆Fe降低，Tf和TIBC升高。ID和IDMn幼仔的脑铁水平均降低，铜水平升高;此外，IDMn幼仔的其他几种必需金属（包括Mn、铬、锌、钴、铝、钼和钒）的脑水平也升高。同时改变浓度的金属在大脑中，转运蛋白二价金属转运蛋白-1和转铁蛋白受体增加。神经递质γ-氨基丁酸和谷氨酸没有显著变化。本研究结果证实，脑中几种必需金属之间存在着稳态关系，而不仅仅是Fe和Mn之间。
Manganese (Mn) neurotoxicity in adults can result in psychological and neurological disturbances similar to Parkinson's disease, including extrapyramidal motor system defects and altered behaviors. Iron (Fe) deficiency is one of the most prevalent nutritional disorders in the world, affecting approximately 2 billion people, especially pregnant and lactating women, infants, toddlers, and adolescents. Fe deficiency can enhance brain Mn accumulation even in the absence of excess Mn in the environment or the diet. To assess the neurochemical interactions of dietary Fe deficiency and excess Mn during development, neonatal rats were exposed to either a control diet, a low-Fe diet (ID), or a low-Fe diet supplemented with Mn (IDMn) via maternal milk during the lactation period (postnatal days [PN] 4-21). In PN21 pups, both the ID and IDMn diets produced changes in blood parameters characteristic of Fe deficiency: decreased hemoglobin (Hb) and plasma Fe, increased plasma transferrin (Tf), and total iron binding capacity (TIBC). Treated ID and IDMn dams also had decreased Hb throughout lactation and ID dams had decreased plasma Fe and increased Tf and TIBC on PN21. Both ID and IDMn pups had decreased Fe and increased copper brain levels; in addition, IDMn pups also had increased brain levels of several other essential metals including Mn, chromium, zinc, cobalt, aluminum, molybdenum, and vanadium. Concurrent with altered concentrations of metals in the brain, transport proteins divalent metal transporter-1 and transferrin receptor were increased. No significant changes were determined for the neurotransmitters gamma aminobutyric acid and glutamate. The results of this study confirm that there is homeostatic relationship among several essential metals in the brain and not simply between Fe and Mn.