Nanoporous membrane robustness / stability in small form factor microfluidic filtration system.
Nanoporous membrane robustness / stability in small form factor microfluidic filtration system.
复制标题
小型型微流体过滤系统中的纳米孔膜鲁棒性 /稳定性。
DOI：
10.1109/embc.2016.7591106
复制
发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
McGrath JL
中科院分区：
文献类型：
--
作者：
Johnson DG;Pan S;Hayden A;McGrath JL
可穿戴式血液透析 (HD) 设备的开发取代了基于中心的血液透析，有望改善终末期肾病 (ERD) 患者的治疗结果和生活质量。这些设备的先决条件是开发高效膜，可以在较小的占地面积内实现高毒素清除率。我们课题组开发的超薄纳米多孔膜材料比传统HD膜的渗透性高出几个数量级。我们报告了可穿戴式透析装置原型的制作进展。首先，我们提供了台式研究的数据，证实可以在低血流率的小动物模型中获得尿素清除率的临床水平。其次，我们报告了提高高膜面积透析装置机械稳健性的努力。
The development of wearable hemodialysis (HD) devices that replace center-based HD holds the promise to improve both outcomes and quality-of-life for patients with end-stage-renal disease (ERD). A prerequisite for these devices is the development of highly efficient membranes that can achieve high toxin clearance in small footprints. The ultrathin nanoporous membrane material developed by our group is orders of magnitude more permeable than conventional HD membranes. We report on our progress making a prototype wearable dialysis unit. First, we present data from benchtop studies confirming that clinical levels of urea clearance can be obtained in a small animal model with low blood flow rates. Second, we report on efforts to improve the mechanical robustness of high membrane area dialysis devices.