TranScout: prediction of gene expression regulatory proteins from their sequences
TranScout: prediction of gene expression regulatory proteins from their sequences
复制标题
DOI：
10.1093/bioinformatics/18.4.597
复制
发表时间：
2002-04-01
期刊：
影响因子：
5.8
通讯作者：
Querol, E
中科院分区：
文献类型：
--
作者：
Aguilar, D;Oliva, B;Querol, E
动机：基因组学的出现产生了成千上万的阅读框架来寻找功能。蛋白质序列中保守功能基序的识别有助于功能预测。结果：设计了一个已报道的DNA结合蛋白基序数据库和分类。已经开发了一个程序（'TranScout'）用于检测和评价具有基因调节功能的蛋白质的原核和真核序列中的保守基序。该程序的效率显示在一个基准对数据库从SWISS-PROT没有用于训练程序的蛋白质序列。所有基序的平均灵敏度为0.98，平均特异性为0.92。可用性：该程序可在互联网上免费获得，网址为http://luz.uab.es/transcout/。用户可以在这个网站上找到更多的信息。联系人：Enric. uab.es; boliva@imim.es。
Motivation: The advent of genomics yields thousands of reading frames in search of function. Identification of conserved functional motifs in protein sequences can be helpful for function prediction.Results: A database and a classification of reported DNA-binding protein motifs has been designed. A program ('TranScout') has been developed for the detection and evaluation of conserved motifs in prokaryotic and eukaryotic sequences of proteins with a gene regulatory function. The efficiency of the program is shown in a benchmark against a database obtained from SWISS-PROT without the protein sequences used to train the program. All motifs were detected with a mean average sensitivity of 0.98 and a mean average specificity of 0.92.Availability: The program is freely available for use on the internet at http://luz.uab.es/transcout/. The user can find additional information at this site.Contact: Enric.Querol@uab.es; boliva@imim.es.