Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements.
Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements.
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DOI：
10.1016/j.neuron.2019.08.029
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发表时间：
2019-11-20
期刊：
影响因子：
16.2
通讯作者：
Klein R
中科院分区：
文献类型：
--
作者：
Paixão S;Loschek L;Gaitanos L;Alcalà Morales P;Goulding M;Klein R
触觉刺激由脊髓深部背角的神经元回路整合和处理。一些脊髓中间神经元与触觉信息处理有关。然而，参与将触觉信息传递到大脑的突触后背柱(PSDC)通路的背角投射神经元的特征很差。在这里，我们展示了由Zic2creer表达标记的脊髓神经元介导了光触摸敏感性和纹理辨别。Zic2creer神经元的一个子集是投射到脑干背柱核团的PSDC神经元，而Zic2 PSDC神经元的化学生成激活增加了对光触摸刺激的敏感性。ZIC2神经元接受皮质和脑干运动核的直接输入，是矫正运动所必需的。这些结果表明，Zic2神经元整合了来自皮肤传入的感觉输入和来自大脑的下行信号，以促进矫正运动，并将处理后的触摸信息传输回大脑。背柱投射将触摸信息从脊髓传递到大脑。Paixão等人。描述Zic2神经元对这一投射的贡献。Zic2神经元还将感觉反馈与来自大脑的信息相结合，以产生适当的运动。
Tactile stimuli are integrated and processed by neuronal circuits in the deep dorsal horn of the spinal cord. Several spinal interneuron populations have been implicated in tactile information processing. However, dorsal horn projection neurons that contribute to the postsynaptic dorsal column (PSDC) pathway transmitting tactile information to the brain are poorly characterized. Here, we show that spinal neurons marked by the expression of Zic2creER mediate light touch sensitivity and textural discrimination. A subset of Zic2creER neurons are PSDC neurons that project to brainstem dorsal column nuclei, and chemogenetic activation of Zic2 PSDC neurons increases sensitivity to light touch stimuli. Zic2 neurons receive direct input from the cortex and brainstem motor nuclei and are required for corrective motor movements. These results suggest that Zic2 neurons integrate sensory input from cutaneous afferents with descending signals from the brain to promote corrective movements and transmit processed touch information back to the brain. The dorsal column projection transmits touch information from the spinal cord to the brain. Paixão et al. describe that Zic2 neurons contribute to this projection. Zic2 neurons also integrate sensory feedback with information from the brain to generate appropriate movements.
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影响因子：
16.2
作者：
Cui, Lian;Miao, Xuerong;Liang, Lingli;Abdus-Saboor, Ishmail;Olson, William;Fleming, Michael S.;Ma, Minghong;Tao, Yuan-Xiang;Luo, Wenqin
通讯作者：
Luo, Wenqin
影响因子：
64.5
作者：
Duan B;Cheng L;Bourane S;Britz O;Padilla C;Garcia-Campmany L;Krashes M;Knowlton W;Velasquez T;Ren X;Ross S;Lowell BB;Wang Y;Goulding M;Ma Q
通讯作者：
Ma Q
影响因子：
4.6
作者：
Ding, YQ;Yin, J;Chen, ZF
通讯作者：
Chen, ZF
DOI：
10.1006/bbrc.1997.7124
发表时间：
1997-08-28
影响因子：
3.1
作者：
Feil, R;Wagner, J;Chambon, P
通讯作者：
Chambon, P
影响因子：
4.6
作者：
Glasgow, SM;Henkel, RM;Johnson, JE
通讯作者：
Johnson, JE