Protein starvation and the small intestine. II. Disaccharidase activities.
Protein starvation and the small intestine. II. Disaccharidase activities.
复制标题
蛋白质饥饿和小肠。
DOI：
10.1016/s0016-5085(19)34073-9
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发表时间：
1968
期刊：
影响因子：
29.4
通讯作者：
F. Kern
中科院分区：
文献类型：
--
作者：
J. Prosper;R. Murray;F. Kern
2.年轻雄性Holtzman大鼠喂食合成27%蛋白质饮食，4只大鼠，或无蛋白质饮食，8只大鼠，持续45天； 5只大鼠被强制喂食蛋白质饮食，8只大鼠被强制喂食无蛋白质饮食10至20天。缺乏蛋白质的大鼠体重减轻、体质虚弱，小肠细、直径小、短，空肠肌基本正常，但回肠肌萎缩。剥夺蛋白质 45 天的大鼠的体重、粘膜重量、粘膜蛋白浓度和总粘膜蛋白均低于对照组。两组之间的二糖酶活性没有显着差异，但剥夺组大鼠肠道第 3 段的蔗糖酶活性高于对照组大鼠。剥夺大鼠全肠中每种二糖酶的总活性下降，但以每100克体重计算时，两组的总活性相似。蛋白质缺乏组的体重减轻并未因强制喂养而减少，并且粘膜重量显着下降。 20天时，强行剥夺大鼠的体重为对照组的44%，粘膜重量为对照组的64%；双糖酶活性没有一致的差异。 P.W.
2. Young male Holtzman rats were fed on a synthetic 27% protein diet, 4 rats, or a protein-free diet, 8 rats for 45 days; 5 rats were forcibly fed with the protein diet and 8 with the protein-free diet for 10 to 20 days. The protein-deprived rats lost weight and became weaker, the small intestine was thin, small in diameter and short, the jejunal muscle was fairly normal but the ileal muscle atrophied. Bodyweight, mucosal weight, mucosal protein concentration and total mucosal protein were lower in rats deprived of protein for 45 days than in controls. Disaccharidase activities were not significantly different between the 2 groups but sucrase activity in segment 3 of the intestine was greater in deprived than on control rats. The total activity of each disaccharidase in whole intestine of deprived rats decreased but when calculated per 100 g bodyweight it was similar in both groups. Weight loss in the protein-deficient group did not decrease with forced feeding and the mucosal weight decreased significantly. At 20 days the bodyweight of deprived forcibly fed rats was 44% that of controls and mucosal weight was 64% that of controls; there were no consistent differences in disaccharidase activities. P. W.