Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma
Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma
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DOI：
10.1007/s00134-004-2184-x
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发表时间：
2004-07-01
影响因子：
38.9
通讯作者：
Ankersmit, HJ
中科院分区：
文献类型：
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作者：
Brunner, M;Krenn, C;Ankersmit, HJ
Objective. T1/ST 2是白细胞介素（IL）-1受体超家族的成员，主要表达于2型辅助性T细胞（Th 2）而非Th 1细胞，并在细胞增殖和Th 2免疫应答中起作用。脓毒症和创伤患者中可溶性ST 2、Th 1-Th 2细胞因子谱和免疫球蛋白（IG）产生的关系尚不清楚。设计和设置。一所大学医院重症监护病房的病例对照研究。患者15例患者在诊断脓毒症后24-48 h内招募，13例创伤患者在入住ICU后24 h内招募，11例接受腹部手术的患者和15例健康志愿者作为对照。测量和结果。采用ELISA法检测血清可溶性ST 2、IL-2、IFN-γ、IL-10和IG的产生。脓毒症患者血清可溶性ST 2水平（8420+/-2169 pg/ml）显著高于创伤（2936+/-826 pg/ml）、腹部手术（1423+/-373 pg/ml）和健康对照组（316+/-72 pg/ml; p
Objective. T1/ST2, a member of the interleukin (IL)-1 receptor superfamily, is predominantly expressed on type-2 T helper (Th2) cells but not Th1 cells, and plays a role in cell proliferation and Th2 immune response. The relation of soluble ST2, Th1-Th2 cytokine profile, and immunoglobulin (Ig) production in sepsis and trauma patients is not well known. Design and setting. Case-control study at a university hospital intensive care unit. Patients. Fifteen patients recruited within 24-48 h of diagnosis of sepsis, 13 trauma patients recruited within 24 h after admission to the ICU, 11 patients who underwent abdominal surgery, and 15 healthy volunteers served as control. Measurements and results. ELISA was utilized to detect serum soluble ST2, IL-2, IFN-gamma, IL-10, and Ig production. Serum levels of soluble ST2 were significantly increased in septic patients (8420+/-2169 pg/ml) as compared with trauma (2936+/-826 pg/ml), abdominal surgery (1423+/-373 pg/ml), and healthy controls (316+/-72 pg/ml; p