Grape-seed polyphenolic extract improves the eye phenotype in a Drosophila model of tauopathy.
Grape-seed polyphenolic extract improves the eye phenotype in a Drosophila model of tauopathy.
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DOI：
10.4061/2010/576357
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发表时间：
2010-08-24
影响因子：
--
通讯作者：
Pasinetti, Giulio M
中科院分区：
文献类型：
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作者：
Pfleger, Cathie M;Wang, Jun;Pasinetti, Giulio M
已经通过转基因过表达疾病相关形式的tau来开发tau蛋白病的果蝇模型。在本文中，我们首次报道了最近开发的葡萄籽多酚提取物（GSPE）改善了果蝇眼模型R406 W tau的眼表型。GSPE介导的蛋白质错误折叠/聚集的这种独特的体内神经变性模型的改善表明，GSPE可能在涉及异常蛋白质聚集的疾病中具有治疗价值。
Drosophila models of tauopathies have been developed by transgenically overexpressing the disease-associated forms of tau. In this paper we report for the first time that a recently developed Grape-Seed Polyphenolic Extract (GSPE) improves the eye phenotype of a Drosophila eye model of R406W tau. GSPE-mediated improvements in this distinct in vivo neurodegeneration model for protein misfolding/aggregation suggest that GSPE may have therapeutic value in disorders involving aberrant protein aggregation.