Two new neo-clerodane diterpenoids from Scutellaria barbata
Two new neo-clerodane diterpenoids from Scutellaria barbata
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DOI：
10.1111/j.1744-7909.2008.00672.x
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发表时间：
2008-06-01
影响因子：
11.4
通讯作者：
Ren, Yan
中科院分区：
文献类型：
--
作者：
Dai, Sheng-Jun;Shen, Li;Ren, Yan
从半枝莲全草中分离得到两个新的新克罗烷二萜化合物，6，7-二苯甲酰氧基巴巴丁C（1，命名为巴巴丁D）和6-（2-乙酰氧基-3-甲基丁酰氧基）-7-（2-羰基-3-甲基丁酰氧基）巴巴丁C（2，命名为巴巴丁E）。唐你它们的结构通过光谱方法包括广泛的ID和2D NMR分析进行了鉴定。在体外，化合物1-2显示出对三种人癌细胞系，即HONE-1鼻咽癌、KB口腔表皮样癌和HT 29结肠直肠癌细胞的细胞毒活性，IC（50）值在3.5-6.7 μ M的范围内。
Two new neo-clerodane diterpenoids, 6,7-dibenzoyloxybarbatin C (1, named barbatin D) and 6-(2-acetoxy-3-methylbutanoloxy)-7-(2-carbonyl-3-methylbutanoyloxy) barbatin C (2, named barbatin E) were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated by spectroscopic methods including extensive I D and 2D NMR analyses. In vitro, compounds 1-2 showed cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC(50) values in the range of 3.5-6.7 mu M.