Ovarian cycle and sympathoexcitation in premenopausal women.
Ovarian cycle and sympathoexcitation in premenopausal women.
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DOI：
10.1161/hypertensionaha.112.202598
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发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Joyner MJ
中科院分区：
文献类型：
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作者：
Carter JR;Fu Q;Minson CT;Joyner MJ
卵巢周期对肌肉交感神经活动（MSNA）的影响仍然存在争议。一些研究报告，与卵泡早期（EF）相比，卵巢周期的黄体中期（ML）期间静息MSNA增加，而其他研究则没有。这些不一致的发现可能部分是由于雌二醇和/或孕酮的波动。我们检验了ML期交感神经兴奋程度（ΔMSNA）与雌二醇（ΔE2）和孕酮（ΔP）变化相关的假设。对30名女性（年龄28±1岁，体重指数23±0 kg/m2）的既往研究数据进行多元回归分析，并完整记录EF和ML期的平均动脉压（MAP）、MSNA、E2和P。ML期增加E2（37±2至117±9 pg/ml; p<0.001）、P（1±0至11±1 ng/ml; p<0.001）和MSNA（12±1至15±1爆发/min; p= 0.02），但不改变MAP（83±2至83±2 mmHg; p= 0.91）。ΔMSNA与ΔE2（r=-0.50，p= 0.003）和ΔE2/ΔP（r=-0.52，p= 0.002）相关，但与ΔP无关（r= 0.21，p= 0.13）。ΔMAP与ΔE2（r=-0.13，p= 0.49）、ΔP（r=-0.04，p= 0.83）或ΔE2/ΔP（r<0.01，p= 0.98）之间没有关联。总之，交感神经兴奋在ML阶段的卵巢周期似乎是依赖的，在一定程度上，性类固醇激增。E2，P和MSNA之间的这种动态相互作用可能解释了先前在该领域报道的不一致性;其他性类固醇，如睾酮，可能解释进一步的差异。
The influence of the ovarian cycle on muscle sympathetic nerve activity (MSNA) remains controversial. Some studies report an increase of resting MSNA during the midluteal (ML) phase of the ovarian cycle compared to the early follicular phase (EF), while others do not. These inconsistent findings may be due, in part, to the variable surges in estradiol and/or progesterone. We tested the hypothesis that the degree of sympathoexcitation during the ML phase (ΔMSNA) is associated with changes in estradiol (ΔE2) and progesterone (ΔP). Multiple regression analysis of data from previous studies with complete recordings of mean arterial pressure (MAP), MSNA, E2, and P during both EF and ML phases were available from 30 eumenorrheic women (age, 28±1 yr; BMI, 23±0 kg/m2). ML phase increased E2 (37±2 to 117±9 pg/ml; p<.001), P (1±0 to 11±1 ng/ml; p<.001), and MSNA (12±1 to 15±1 bursts/min; p=.02), but did not alter MAP (83±2 to 83±2 mmHg; p=.91). ΔMSNA was correlated to ΔE2 (r=−.50, p=.003) and ΔE2/ΔP (r=−.52, p=.002), but not ΔP (r=.21, p=.13). There was no association between ΔMAP and ΔE2 (r=−.13, p=.49), ΔP (r=−.04, p=.83), or ΔE2/ΔP (r<.01, p=.98). In conclusion, sympathoexcitation during the ML phase of the ovarian cycle appears to be dependent, in part, upon the degree of sex steroid surges. This dynamic interaction between E2, P, and MSNA likely explains previously reported inconsistencies in the field; it remains possible that other sex steroids, such as testosterone, might explain further variance.