ULTRASTRUCTURAL EVIDENCE FOR THE COEXISTENCE OF CALCITONIN GENE-RELATED PEPTIDE AND SUBSTANCE-P IN SECRETORY VESICLES OF PERIPHERAL-NERVES IN THE GUINEA-PIG
ULTRASTRUCTURAL EVIDENCE FOR THE COEXISTENCE OF CALCITONIN GENE-RELATED PEPTIDE AND SUBSTANCE-P IN SECRETORY VESICLES OF PERIPHERAL-NERVES IN THE GUINEA-PIG
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DOI：
10.1007/bf01611735
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发表时间：
1986-08-01
期刊：
影响因子：
--
通讯作者：
POLAK, JM
中科院分区：
文献类型：
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作者：
GULBENKIAN, S;MERIGHI, A;POLAK, JM
Using double immunogold staining procedures, calcitonin gene-related peptide (CGRP)-like and substance P (SP)-like immunoreactivities were localized at the ultrastructural level to guinea pig trigeminal ganglia, dorsal root ganglia and peripheral nerve fibres associated with the vascular system. CGRP-like and SP-like immunoreactivities were found consistently in large granular secretory vesicles (70-100 nm in diameter), and both peptide immunoreactivities were co-localized to the same vesicle in both sensory ganglion cells and within axons and their terminals in the adventitia and adventitial-medial border of the superior mesenteric artery. These results suggest that CGRP and SP are co-stored and may be released together from peripheral axons in the guinea pig.
