Bundle-Specific Axon Diameter Index as a New Contrast to Differentiate White Matter Tracts.
Bundle-Specific Axon Diameter Index as a New Contrast to Differentiate White Matter Tracts.
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DOI：
10.3389/fnins.2021.646034
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发表时间：
2021
影响因子：
4.3
通讯作者：
Daducci A
中科院分区：
文献类型：
--
作者：
Barakovic M;Girard G;Schiavi S;Romascano D;Descoteaux M;Granziera C;Jones DK;Innocenti GM;Thiran JP;Daducci A
在灵长类动物的中枢神经系统中，多种通路的特征在于不同的轴突直径谱。基于扩散加权磁共振成像的体内方法可以非侵入性地提供轴突直径指数估计。然而，此类方法报告了体素方面的估计，由于来自具有不同微观结构特性的其他途径的部分体积贡献，对于相同的白质束，体素之间的估计各不相同。在这里，我们提出了一种新颖的微观结构信息纤维束成像方法 COMMITAxSize，以在流线水平上解决轴突直径指数估计，从而使估计沿轨迹不变。与之前提出的体素方法相比，我们的公式允许直接估计每个流线的不同轴突直径指数值，为沿束的平均值的现有计算提供补充测量。我们将我们的估计与在胼胝体和内囊后肢进行的现有组织学测量进行比较，证明了我们的方法的良好性能。总的来说，我们的方法通过联合估计组织的微观结构特性和白质连接的宏观组织，提供了对通路轴突直径指数的更稳健的估计。
In the central nervous system of primates, several pathways are characterized by different spectra of axon diameters. In vivo methods, based on diffusion-weighted magnetic resonance imaging, can provide axon diameter index estimates non-invasively. However, such methods report voxel-wise estimates, which vary from voxel-to-voxel for the same white matter bundle due to partial volume contributions from other pathways having different microstructure properties. Here, we propose a novel microstructure-informed tractography approach, COMMITAxSize, to resolve axon diameter index estimates at the streamline level, thus making the estimates invariant along trajectories. Compared to previously proposed voxel-wise methods, our formulation allows the estimation of a distinct axon diameter index value for each streamline, directly, furnishing a complementary measure to the existing calculation of the mean value along the bundle. We demonstrate the favourable performance of our approach comparing our estimates with existing histologically-derived measurements performed in the corpus callosum and the posterior limb of the internal capsule. Overall, our method provides a more robust estimation of the axon diameter index of pathways by jointly estimating the microstructure properties of the tissue and the macroscopic organisation of the white matter connectivity.
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影响因子：
5.7
作者：
Barakovic M;Tax CMW;Rudrapatna U;Chamberland M;Rafael-Patino J;Granziera C;Thiran JP;Daducci A;Canales-Rodríguez EJ;Jones DK
通讯作者：
Jones DK
影响因子：
48
作者：
Craddock, R. Cameron;Jbabdi, Saad;Yan, Chao-Gan;Vogelstein, Joshua T.;Castellanos, F. Xavier;Di Martino, Adriana;Kelly, Clare;Heberlein, Keith;Colcombe, Stan;Milham, Michael P.
通讯作者：
Milham, Michael P.
影响因子：
5.7
作者：
Daducci, Alessandro;Canales-Rodriguez, Erick J.;Thiran, Jean-Philippe
通讯作者：
Thiran, Jean-Philippe
影响因子：
14.5
作者：
DeLuca, GC;Ebers, GC;Esiri, MM
通讯作者：
Esiri, MM
影响因子：
3.7
作者：
Archer, Derek B.;Vaillancourt, David E.;Coombes, Stephen A.
通讯作者：
Coombes, Stephen A.