Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis.
Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis.
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DOI：
10.1021/jacs.7b00049
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发表时间：
2017-02
影响因子：
15
通讯作者：
Ryosuke Takise;Ryota Isshiki;K. Muto;K. Itami;Junichiro Yamaguchi
中科院分区：
文献类型：
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作者：
Ryosuke Takise;Ryota Isshiki;K. Muto;K. Itami;Junichiro Yamaguchi
由于二芳基醚作为重要的基序存在于药物和天然产物中，因此已经进行了广泛的研究以开发新的方法。构建二芳醚部分的常规方法是芳基卤和苯酚与铜或钯催化剂的分子间交叉偶联反应。我们开发了一种使用钯或镍催化剂与我们的使能双膦配体的芳香酯的催化脱羰基醚化反应，得到相应的二芳基醚。本发明的反应可以在克规模上以优异的产率进行。该反应不仅在分子内环境中起作用，而且还允许使用其他酚类进行交叉醚化。
Because diaryl ethers are present as an important motif in pharmaceuticals and natural products, extensive studies for the development of novel methods have been conducted. A conventional method for the construction of the diaryl ether moiety is the intermolecular cross-coupling reaction of aryl halides and phenols with a copper or palladium catalyst. We developed a catalytic decarbonylative etherification of aromatic esters using a palladium or nickel catalyst with our enabling diphosphine ligand to give the corresponding diaryl ethers. The present reaction can be conducted on gram scale in excellent yield. This reaction not only functions in an intramolecular setting but also allows for a cross-etherification using other phenols.