Maximum voluntary activation in nonfatigued and fatigued muscle of young and elderly individuals
Maximum voluntary activation in nonfatigued and fatigued muscle of young and elderly individuals
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DOI：
10.1093/ptj/81.5.1102
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发表时间：
2001-05-01
期刊：
影响因子：
3.2
通讯作者：
Binder-Macleod, SA
中科院分区：
文献类型：
--
作者：
Stackhouse, SKS;Stevens, JE;Binder-Macleod, SA
背景和目的。研究老年人（大于或等于65岁）肌肉中枢激活的研究人员有。仅在非疲劳状态下研究激活。本研究考察了年轻人和老年人在疲劳和非疲劳状态下主动激活股四头肌的能力，以确定中枢激活失败对与年龄相关的力量丧失的影响。研究对象和方法。本研究共纳入20名青年受试者（男性11名，女性9名，平均年龄22.67岁，SD = 4.14，范围18-32岁）和17名老年受试者（男性8名，女性9名，平均年龄71.5岁，SD = 5.85，范围65-84岁）。受试者坐在测功机上并保持稳定。中枢激活是量化的，基于在3到5秒的股四头肌最大自主收缩（MVC）过程中产生的100赫兹，12脉冲的电流序列所产生的力的变化。接下来，受试者进行25次MVCs（5秒收缩，休息2秒）来疲劳肌肉。在最后一次MVC期间，再次测量中央激活。结果。在非疲劳状态下，老年受试者的中枢激活低于年轻受试者，在疲劳状态下，这种差异变得更大。讨论与结论。与年轻受试者相比，老年受试者在疲劳和非疲劳状态下的股四头肌中枢激活都减少了。因此，与年龄相关的虚弱的相同部分可能归因于疲劳和非疲劳状态下中枢激活的失败。
Background and Purpose. Researchers studying central activation of muscles in elderly subjects (greater than or equal to 65 years of age) have. investigated activation in only the nonfatigued state. This study examined the ability of young and elderly people to activate their quadriceps femoris muscles voluntarily under both fatigued and nonfatigued conditions to determine the effect of central activation failure on age-related loss of force. Subjects and Methods. Twenty young subjects (11 men, 9 women; mean age = 22.67 years, SD = 4.14, range = 18-32 years) and 17 elderly subjects (8 men, 9 women; mean age = 71.5 years, SD = 5.85, range = 65-84, years) participated in this study. Subjects were seated on a dynamometer and stabilized. Central activation was quantified, based on the change in force produced by a 100-Hz, 12-pulse electrical train that was delivered during a 3- to 5-second isometric maximum voluntary contraction (MVC) of the quadriceps femoris muscle. Next, subjects performed 25 MVCs (a 5-second contraction with 2 seconds of rest) to fatigue the muscle. During the last MVC, central activation was measured again. Results. In the nonfatigued state, elderly subjects had lower central activation than younger subjects, in the fatigued state, this difference became larger. Discussion and Conclusion. Central activation of the quadriceps femoris muscle in elderly subjects was reduced in both the fatigued and nonfatigued stares when compared with young subjects. Same part of age-related weakness, therefore, may be attributed to failure of central activation in both the fatigued and nonfatigued states.