Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls.
Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls.
复制标题
锂对双相情感障碍（躁狂抑郁症）患者和健康对照者血小板离子胞内钙浓度的影响。
DOI：
10.1016/0024-3205(90)90454-y
复制
发表时间：
1990
期刊：
影响因子：
6.1
通讯作者：
Bowden,CL
中科院分区：
文献类型：
--
作者：
Tan,CH;Javors,MA;Seleshi,E;Lowrimore,PA;Bowden,CL
锂是治疗双相情感障碍的躁狂和抑郁发作的有效药物。锂已被证明可以阻断细胞内第二信使肌醇 1,4,5-三磷酸的代谢，其参与细胞内离子钙 ([Ca++]i) 的增加，从而触发分泌细胞中的神经递质释放和其他细胞变化。我们测量了锂对经锂治疗稳定的双相情感障碍患者和健康对照的血小板 [Ca++] 动力学的影响。双相情感障碍患者的静息 [Ca++] 和凝血酶刺激的 [Ca++] 增加均高于对照组。体外添加的锂倾向于增加凝血酶刺激的[Ca++]i 升高。在人血小板中使用荧光 Ca++ 探针 fura-2 为研究锂在双相情感障碍中的作用机制以及研究双相情感障碍中可能异常的 Ca++ 相关系统提供了有用的方法。
Lithium is an effective drug in the treatment of both manic and depressive episodes of bipolar disorder. Lithium has been shown to block the metabolism of the intracellular second messenger inositol-1,4,5-trisphosphate which is involved in the rise in ionic intracellular calcium ([Ca++]i) which triggers neurotransmitter release and other cellular changes in secretory cells. We have measured the effect of lithium on [Ca++]idynamics in platelets from bipolar patients stabilized with lithium treatment, and from healthy controls. Both resting [Ca++]iand the thrombin stimulated increase in [Ca++]iwere higher in bipolar patients than in controls. Lithium addedin vitrotended to increase the thrombin-stimulated rise in [Ca++]i. The use of the fluorescent Ca++probe fura-2 in human platelets provides a useful method to investigate the mechanism of lithium's action in bipolar disorder and to study Ca++related systems which may be abnormal in bipolar disorders.