Translational Genomic Research: Protocol Development and Initial Outcomes following SNP Testing for Colon Cancer Risk.
Translational Genomic Research: Protocol Development and Initial Outcomes following SNP Testing for Colon Cancer Risk.
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DOI：
10.1007/s13142-012-0149-0
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发表时间：
2013-03-01
影响因子：
3.6
通讯作者：
Graves, Kristi D.
中科院分区：
文献类型：
--
作者：
Nusbaum, Rachel;Leventhal, Kara-Grace;Hooker, Gillian W.;Peshkin, Beth N.;Butrick, Morgan;Salehizadeh, Yasmin;Tuong, William;Eggly, Susan;Mathew, Jeena;Goerlitz, David;Shields, Peter G.;Schwartz, Marc D.;Graves, Kristi D.
关键词：
虽然单核苷酸多态性（SNP）检测疾病的易感性是商业化的，翻译研究是必要的，以了解如何沟通基因组信息和潜在的影响，为公共卫生。我们探讨了对结肠癌风险基因组检测的态度和初步反应。在开发教育材料之后，我们在初级保健患者的试点研究中提供了三种结肠癌SNP的测试。参与者完成了测试前和测试后的会议和访谈。我们使用主位分析的定性软件对访谈记录进行分析。所有20名参与者都选择了SNP测试。定性分析确定了几个主题：SNP测试的动机，之前/之后：结果的意义，SNP结果的情感反应和基因组素养/信息传递。结果表明，个人将追求SNP测试的背景下，测试前和测试后的教育。SNP结果可能会影响健康饮食和运动等健康行为，但似乎不会影响结肠癌筛查的意图。
Although single nucleotide polymorphism (SNP) testing for disease susceptibility is commercially available, translational studies are necessary to understand how to communicate genomic information and potential implications for public health. We explored attitudes about and initial responses to genomic testing for colon cancer risk. Following development of the educational materials, we offered testing for three colon cancer SNPs in a pilot study with primary care patients. Participants completed pre- and post-test sessions and interviews. We analyzed interview transcripts with qualitative software using thematic analysis. All 20 participants opted for SNP testing. Qualitative analysis identified several themes: Motivations for SNP Testing, Before/After: Meaning of Results, Emotional Responses to SNP Results and Genomic Literacy/ Information Delivery. Results demonstrate that individuals will pursue SNP testing in the context of pre and post-test education. SNP results may influence health behaviors like healthy eating and exercise yet did not appear to impact colon cancer screening intentions.
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影响因子：
2.7
作者：
Bunnik, Eline M.;Schermer, Maartje H. N.;Janssens, A. Cecile J. W.
通讯作者：
Janssens, A. Cecile J. W.
DOI：
10.1038/gim.2012.22
发表时间：
2012-07
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
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作者：
通讯作者：
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影响因子：
30.8
作者：
Jaeger, Emma;Webb, Emily;Tomlinson, Ian
通讯作者：
Tomlinson, Ian
影响因子：
3.2
作者：
Cameron, LD;Diefenbach, MA
通讯作者：
Diefenbach, MA
DOI：
10.1177/0272989x11393976
发表时间：
2011-11
期刊：
Medical decision making : an international journal of the Society for Medical Decision Making
影响因子：
--
作者：
Han PK;Klein WM;Arora NK
通讯作者：
Arora NK