Family with sequence similarity 83, member B is a predictor of poor prognosis and a potential therapeutic target for lung adenocarcinoma expressing wild-type epidermal growth factor receptor.
Family with sequence similarity 83, member B is a predictor of poor prognosis and a potential therapeutic target for lung adenocarcinoma expressing wild-type epidermal growth factor receptor.
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具有序列相似性的家族83，成员B是预后不良的预测指标，也是表达野生型表皮生长因子受体的肺腺癌的潜在治疗靶标。
DOI：
10.3892/ol.2017.7517
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发表时间：
2018-03
期刊：
影响因子：
2.9
通讯作者：
Suzuki H
中科院分区：
文献类型：
--
作者：
Yamaura T;Ezaki J;Okabe N;Takagi H;Ozaki Y;Inoue T;Watanabe Y;Fukuhara M;Muto S;Matsumura Y;Hasegawa T;Hoshino M;Osugi J;Shio Y;Waguri S;Tamura H;Imai JI;Ito E;Yanagisawa Y;Honma R;Watanabe S;Suzuki H
肺腺癌(ADC)患者的肿瘤不存在靶向驱动基因突变，如表皮生长因子受体(EGFR)基因突变，预后不良，因此需要新的治疗靶点。序列相似性83的家族成员B(FAM83B)是鳞状细胞肺癌的生物标记物。FAM83B最近也被证明在EGFR信号通路中发挥重要作用。本研究探讨了FAM83B对肺ADC的分子和临床作用。取216例接受全肺切除的原发肺ADC患者的肿瘤组织和癌旁正常组织标本，用基因芯片技术检测FAM83B的表达。研究FAM83B的表达与包括患者生存在内的临床病理参数之间的关系。FAM83B在男性、吸烟者和带有野生型EGFR的肿瘤中高表达。多因素分析进一步证实野生型EGFR肿瘤与FAM83B表达呈显著正相关。在生存分析中，FAM83B的表达与无病生存和总体生存的不良结果相关，特别是当与具有野生型EGFR的肿瘤分层时。此外，还利用FAM83B基因敲除技术研究了其对肺ADC细胞系表型的影响。FAM83B RNA干扰抑制HLC-1和H1975肺ADC细胞生长FAM83B可能参与了肺ADC肿瘤的增殖，并可作为预后不良的指标。FAM83B也是治疗野生型EGFR ADC的潜在新靶点。
Lung adenocarcinoma (ADC) patients with tumors that harbor no targetable driver gene mutation, such as epidermal growth factor receptor (EGFR) gene mutations, have unfavorable prognosis, and thus, novel therapeutic targets are required. Family with sequence similarity 83, member B (FAM83B) is a biomarker for squamous cell lung cancer. FAM83B has also recently been shown to serve an important role in the EGFR signaling pathway. In the present study, the molecular and clinical impact of FAM83B in lung ADC was investigated. Matched tumor and adjacent normal tissue samples were obtained from 216 patients who underwent complete lung resection for primary lung ADC and were examined for FAM83B expression using cDNA microarray analysis. The associations between FAM83B expression and clinicopathological parameters, including patient survival, were examined. FAM83B was highly expressed in tumors from males, smokers and in tumors with wild-type EGFR. Multivariate analyses further confirmed that wild-type EGFR tumors were significantly positively associated with FAM83B expression. In survival analysis, FAM83B expression was associated with poor outcomes in disease-free survival and overall survival, particularly when stratified against tumors with wild-type EGFR. Furthermore, FAM83B knockdown was performed to investigate its phenotypic effect on lung ADC cell lines. Gene silencing by FAM83B RNA interference induced growth suppression in the HLC-1 and H1975 lung ADC cell lines. FAM83B may be involved in lung ADC tumor proliferation and can be a predictor of poor survival. FAM83B is also a potential novel therapeutic target for ADC with wild-type EGFR.
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影响因子：
--
作者：
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通讯作者：
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影响因子：
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