Drug release and antioxidant/antibacterial activities of silymarin-zein nanoparticle/bacterial cellulose nanofiber composite films.
Drug release and antioxidant/antibacterial activities of silymarin-zein nanoparticle/bacterial cellulose nanofiber composite films.
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DOI：
10.1016/j.carbpol.2017.09.100
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发表时间：
2018-01
影响因子：
11.2
通讯作者：
Yi-hsuan Tsai;Yu-Ning Yang;Y. Ho;M. Tsai;F. Mi
中科院分区：
文献类型：
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作者：
Yi-hsuan Tsai;Yu-Ning Yang;Y. Ho;M. Tsai;F. Mi
细菌纤维素（BC）是一种由纳米纤维组成的生物聚合物，具有优异的成膜能力。然而，BC不具有抗菌或抗氧化活性，因此限制了BC在食品和生物医学应用中的适用性。在这项研究中，黄酮水飞蓟素（SMN）和玉米醇溶蛋白组装成球形SMN-Zein纳米粒子，可以有效地吸附到BC纳米纤维。SMN-Zein纳米粒子的加入极大地改变了BC膜的润湿性和溶胀性，形成了纳米粒子/纳米纤维纳米复合材料。SMN-玉米醇溶蛋白纳米颗粒增强了微溶水飞蓟素从纳米复合膜中的释放。活性膜显示出更有效的抗氧化和抗菌活性相比，纯BC膜，从而能够保护鲑鱼肌肉从变质和脂质氧化。这些研究结果表明，纳米颗粒/纳米复合材料可以提供一个合适的平台，为改善药物释放性能和生物活性的BC膜的改性。
Bacterial cellulose (BC) is a biopolymer composed of nanofibers which has excellent film-forming ability. However, BC do not have antibacterial or antioxidant activity, thus limiting the applicability of BC for food and biomedical applications. In this study, flavonoid silymarin (SMN) and zein were assembled into spherical SMN-Zein nanoparticles that could be effectively adsorbed onto BC nanofibers. SMN-Zein nanoparticles greatly changed the wettability and swelling property of BC films due to the formation of nanoparticles/nanofibers nanocomposites. SMN-Zein nanoparticles enhanced the release of sparingly soluble silymarin from the nanocomposite films. The active films showed more effective antioxidant and antibacterial activities as compared with pure BC films and thus were able to protect salmon muscle from deterioration and lipid oxidation. These findings suggest that the nanoparticle/nanofiber composites may offer a suitable platform for modification of BC films with improved drug release properties and biological activities.