Normal and hypertrophic growth of the rat heart: changes in cell dimensions and number.
Normal and hypertrophic growth of the rat heart: changes in cell dimensions and number.
复制标题
大鼠心脏的正常和肥大生长：细胞尺寸和数量的变化。
DOI：
10.1152/ajpheart.1978.234.2.h123
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
K. Rakušan
中科院分区：
文献类型：
--
作者：
B. Korecky;K. Rakušan
在正常和刺激的心脏生长过程中，同时测量酶分离的单个大鼠心肌细胞的长度和宽度。在体重在75和750 g之间的正常大鼠中，长度和宽度分别增加了64和68%，而它们的比例保持不变（约100%）。5.3）。根据圆柱模型计算的细胞体积增加了近5倍。发现平均肌细胞体积和左心室质量的增加率相似，表明正常心肌生长可由现有肌细胞肥大解释，不需要增殖。在成年大鼠主动脉缩窄引起的心脏肥大中，观察到细胞体积增加，但未检测到长宽比的显著变化。肥大心脏的细胞体积与从较大的正常大鼠获得的类似重量的心脏中观察到的细胞体积相对应，并且刺激的心脏生长也可以仅由现有细胞的肥大来解释。
The length and width of enzymatically isolated individual rat cardiac myocytes were concurrently measured during normal and stimulated cardiac growth. In normal rats weighing between 75 and 750 g the length and width increased by 64 and 68% while their ratio remained constant (ca. 5.3). The cell volume, calculated on the basis of a cylindrical model, increased almost 5 times. The rates of increase in the volume of an average myocyte and in left ventricular mass were found to be similar, indicating that normal myocardial growth could be explained by hypertrophy of existing myocytes and no proliferation would be required. In cardiomegaly induced by aortic constriction in the adult rat, an increase in cell volume was observed while no significant changes in the length-to-width ratios could be detected. The cell volumes of the hypertrophic hearts corresponded to those observed in hearts of similar weight obtained from larger normal rats and the stimulated cardiac growth could also be explained solely by hypertrophy of existing cells.