Molecular epidemiologic analysis of Staphylococcus aureus isolated from four burn centers
Molecular epidemiologic analysis of Staphylococcus aureus isolated from four burn centers
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DOI：
10.1016/j.burns.2011.12.023
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发表时间：
2012-08-01
期刊：
影响因子：
2.7
通讯作者：
Han, Li-zhong
中科院分区：
文献类型：
--
作者：
Chen, Xu;Yang, Hai-hui;Han, Li-zhong
金黄色葡萄球菌一直是医院获得性感染的主要原因。耐甲氧西林金黄色葡萄球菌（MRSA）自20世纪80年代以来一直是医院的流行病学问题。这种古老的病原体给所有医生和细菌学家带来了新的挑战。因此，迫切需要有效的MRSA控制措施。S.金黄色葡萄球菌或MRSA是烧伤中心感染的主要原因之一，导致许多不良结果甚至死亡。本研究进行了分子流行病学分析的S。金黄色葡萄球菌分离自中国东南部四个烧伤中心。共收集到85个分离物，并对其进行了分子特征鉴定。本研究中发现4个烧伤中心MRSA的流行克隆为SCCmec III（spa-type t030，agr I），对红霉素、克林霉素、卡那霉素和莫匹罗星4种抗菌药物耐药。无意中观察到mecA检测与用于MRSA鉴定的常规检测之间的差异。我们的数据表明MRSA的总患病率为55.3%，磺胺甲恶唑/甲氧苄啶、利奈唑胺和夫西地酸等药物是治疗S.金黄色葡萄球菌或MRSA感染的四个烧伤中心的研究。(c)2012 Elsevier Ltd和ISBI。All rights reserved.
Staphylococcus aureus has been a major cause of hospital-acquired infections. Methicillin-resistant Staphylococcus aureus (MRSA) has emerged since 1980s as an epidemiologic problem in hospitals. This old pathogen brings a new challenge to all physicians and bacteriologists. Hence, effective measures of MRSA control are in critical need. S. aureus or MRSA is one of the leading causes of infection among burn centers, resulting in a number of poor outcomes and even death. The present study performed a molecular epidemiologic analysis of S. aureus isolated from four burn centers in the southeast of China. A total of 85 isolates were collected, and molecular characters were determined for further investigation. In this study, the prevalent clone of MRSA among four burn centers was found to be SCCmec III (spa-type t030, agr I), which is resistant to 4 kinds of antimicrobials including erythromycin, clindamycin, kanamycin and mupirocin. Discrepancy between mecA detection and conventional tests used for MRSA identification was observed unintentionally. Our data demonstrated that the overall prevalence rate of MRSA was 55.3%, and drugs such as sulfamethoxazole/trimethoprim, linezolid and fusidic acid are efficient antibiotic options for treating S. aureus or MRSA infections among four burn centers studied in present investigation. (c) 2012 Elsevier Ltd and ISBI. All rights reserved.