Prolongation of repolarization time by electric field stimulation with monophasic and biphasic shocks in open-chest dogs.
Prolongation of repolarization time by electric field stimulation with monophasic and biphasic shocks in open-chest dogs.
复制标题
通过单相和双相电击的电场刺激延长开胸犬的复极时间。
DOI：
10.1161/01.res.68.6.1761
复制
发表时间：
1991
影响因子：
20.1
通讯作者：
Ideker,RE
中科院分区：
文献类型：
--
作者：
Zhou,XH;Knisley,SB;Wolf,PD;Rollins,DL;Smith,WM;Ideker,RE
最近的研究表明：1) 电诱发纤颤和除颤除了刺激之外还涉及电击不应期的延长；2) 双相波形比可比的单相波形更有效地除颤。本研究的目的是比较起搏节律期间单相和双相电击在 50% 复极时动作电位持续时间的延长。使用浮动玻璃微电极记录七只开胸犬右心室前心外膜的细胞内情况。在间隔为 350 毫秒、5 毫秒和 2.5 毫秒的 10 个 S1 心跳后，通过微电极两侧的网状电极给予单相电击和双相电击，每个相 2.5 毫秒。调整冲击强度，使得从围绕微电极的八个细胞外电极测量的冲击场约为5V/cm。单相和双相 S2 电击从 120 毫秒的 S1-S2 间隔开始，以 5 毫秒的步长增加，直到 S2 电击产生动作电位。单相和双相 5 V/cm 冲击场均导致动作电位持续时间显着延长。动作电位持续时间的延长随着S1-S2间期的增加而增加。 5 毫秒单相电击的 S1-S2 间隔比双相电击的延长时间更短。
Recent studies suggest that 1) electrically induced fibrillation and defibrillation involve prolongation of refractoriness by the shock in addition to stimulation and 2) biphasic waveforms are more efficient for defibrillation than are comparable monophasic waveforms. The purpose of this study was to compare prolongation of action potential duration at 50% repolarization by monophasic and biphasic shocks during paced rhythm. A floating glass microelectrode was used to record intracellularly from the anterior right ventricular epicardium in seven open-chest dogs. After 10 S1 beats paced at an interval of 350 msec, 5-msec and 2.5-msec monophasic shocks and biphasic shocks, with each phase of 2.5 msec, were given via mesh electrodes on either side of the microelectrode. The shock strength was adjusted so that the shock field, measured from eight extracellular electrodes encircling the microelectrode, was about 5 V/cm. Monophasic and biphasic S2 shocks were given starting with an S1-S2 interval of 120 msec, which was increased in 5-msec steps until an action potential was produced by the S2 shock. Both monophasic and biphasic 5 V/cm shock fields caused significant prolongation of action potential duration. The prolongation of action potential duration increased as the S1-S2 interval increased. This prolongation occurred at shorter S1-S2 intervals for 5-msec monophasic shocks than for biphasic shocks.
登录
查看更多内容
心肌纤维的分级和递减反应。
影响因子：
--
作者：
C. Y. Kao;B. Hoffman
通讯作者：
B. Hoffman
心室颤动期间原位心室细胞的细胞内记录。
DOI：
10.1152/ajpheart.1981.240.4.h465
发表时间：
1981
期刊：
The American journal of physiology
影响因子：
--
作者：
Akiyama,T
通讯作者：
Akiyama,T
影响因子：
15.9
作者：
CHEN, PS;SHIBATA, N;IDEKER, RE
通讯作者：
IDEKER, RE
通过双相矩形波形减少除颤器引起的功能障碍。
DOI：
10.1152/ajpheart.1984.247.5.h792
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
--
作者：
Jones,JL;Jones,RE
通讯作者：
Jones,RE
使用双相波形进行心室除颤：相持续时间的重要性。
影响因子：
24
作者：
Tang,AS;Yabe,S;Wharton,JM;Dolker,M;Smith,WM;Ideker,RE
通讯作者：
Ideker,RE