In vitro assays for investigating the FLASH effect.
In vitro assays for investigating the FLASH effect.
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DOI：
10.1017/erm.2022.5
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发表时间：
2022-02-28
影响因子：
6.2
通讯作者：
Petersson, Kristoffer
中科院分区：
文献类型：
--
作者：
Adrian, Gabriel;Ruan, Jia-Ling;Paillas, Salome;Cooper, Christian R.;Petersson, Kristoffer
FLASH放疗是一种新技术，已在许多临床前体内研究中显示，有可能成为癌症治疗的下一个重要改进。然而，负责正常组织的选择性FLASH保留效应的生物学机制尚不清楚。将闪光放射治疗最佳地转化为临床需要很好地了解诱发闪光效应的特定射束参数、影响反应的环境条件以及所涉及的放射生物学机制。尽管闪光效应通常被认为是一种体内效应，但仅在动物身上进行这些答案的研究将是困难的，并且在伦理上具有挑战性。因此，需要进行适当的体外研究，以找到这些答案。在这篇综述中，我们描述和总结了几个体外试验，已被使用或可用于最终阐明FLASH效应背后的机制。
FLASH radiotherapy is a novel technique that has been shown in numerous preclinical in vivo studies to have the potential to be the next important improvement in cancer treatment. However, the biological mechanisms responsible for the selective FLASH sparing effect of normal tissues are not yet known. An optimal translation of FLASH radiotherapy into the clinic would require a good understanding of the specific beam parameters that induces a FLASH effect, environmental conditions affecting the response, and the radiobiological mechanisms involved. Even though the FLASH effect has generally been considered as an in vivo effect, studies finding these answers would be difficult and ethically challenging to carry out solely in animals. Hence, suitable in vitro studies aimed towards finding these answers are needed. In this review, we describe and summarise several in vitro assays that have been used or could be used to finally elucidate the mechanisms behind the FLASH effect.
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影响因子：
2.9
作者：
Al-Ramadan A;Mortensen AC;Carlsson J;Nestor MV
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Nestor MV
DOI：
10.1016/j.ijrobp.2021.03.056
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期刊：
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