Epithelial metabolism of the corneal graft is abnormal.
Epithelial metabolism of the corneal graft is abnormal.
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角膜移植物的上皮代谢异常。
DOI：
10.1136/bjo.71.8.593
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发表时间：
1987
影响因子：
4.1
通讯作者：
D. Sweeney
中科院分区：
文献类型：
--
作者：
A. Vannas;B. Holden;D. Sweeney
本文对16例单侧穿透性角膜移植术患者的双眼进行了检查。移植眼中心的平均吸氧速率为3.88 (SD 0.55) mmHg/s，对照组为4.29 (SD 0.62) mmHg/s。移植物眼和对照眼的颞外周结果分别为4.52 (SD 0.54) mmHg/s和4.26 (SD 0.52) mmHg/s。移植物角膜中心与对侧对照眼、移植物眼中心与外周吸氧率差异均有统计学意义（p < 0.01）。4例移植眼角膜中央触阈恢复良好，其余12例无恢复或恢复程度极低。移植眼和对照眼的中央、颞部上皮和角膜厚度无显著差异。移植眼中心内皮细胞密度为1383个细胞/mm2，对照组为3053个细胞/mm2。由于角膜氧摄取反映了有氧上皮代谢的变化，因此穿透性角膜移植术后移植物上皮神经完整性的丧失与上皮有氧代谢的降低之间可能存在联系。
Both eyes of 16 patients who had undergone unilateral penetrating keratoplasty were examined in this study. The mean corneal oxygen uptake rate in the centre of the graft was 3.88 (SD 0.55) mmHg/s and in the control eye was 4.29 (SD 0.62) mmHg/s. In the temporal host periphery the results for the grafted and control eyes were 4.52 (SD 0.54) mmHg/s and 4.26 (SD 0.52) mmHg/s respectively. The differences in the oxygen uptake rate between the centre of the graft cornea and the contralateral control eye and between the centre and periphery of the graft eye were statistically significant (p less than 0.01). The central corneal touch threshold of the graft eye showed good recovery in four patients, while the remaining 12 had no or minimal recovery. The central and temporal epithelial and corneal thicknesses of the graft and the control eyes were not significantly different. The central endothelial cell density was 1383 cells/mm2 in the graft and 3053 cells/mm2 in the control eye. As corneal oxygen uptake reflects changes in aerobic epithelial metabolism, it is possible that there is a link between loss of neural integrity of graft epithelium and lowered epithelial aerobic metabolism following penetrating keratoplasty.