Enhanced longevity in tau mutant Syrian hamsters, Mesocricetus auratus
Enhanced longevity in tau mutant Syrian hamsters, Mesocricetus auratus
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DOI：
10.1177/07430402017003004
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发表时间：
2002-06-01
影响因子：
3.5
通讯作者：
Daan, S
中科院分区：
文献类型：
--
作者：
Oklejewicz, M;Daan, S
叙利亚仓鼠中的单基因突变tau使纯合突变的昼夜节律周期缩短了约20%，同时使质量特定代谢率增加了约20%。这两种影响可能都会导致寿命的变化。为了测试这种期望值，在持续的黑暗中记录了来自三种基因类型(野生型、杂合型和纯合型tau突变体，都来自杂合子杂交以随机化遗传背景)的雄性和雌性仓鼠的寿命。雄性仓鼠的寿命显著长于雌性仓鼠：总体平均寿命雄性为96.9周(SE=2.5，n=118)，雌性为82.0周(SE=2.1，n=99)。令我们惊讶的是，与野生型相比，雄性和雌性纯合突变仓鼠的寿命明显更长而不是更短。对于男性，这两种基因类型之间的差异平均为14%；对于女性，差异为16%。野生型与tau纯合子的死亡率有显着性差异，但与杂合子的死亡率无显著差异。总体而言，野生型雌鼠的存活率与杂合子和纯合子突变雌鼠的存活率在统计学上是有区别的。在整个生命周期中，雄性和雌性野生型仓鼠都比纯合子突变仓鼠重，杂合子突变仓鼠的体重中等。体重和寿命之间没有相关性，尾部突变仓鼠寿命延长的原因仍未解决。
The single-gene mutation tau in the Syrian hamster shortens the circadian period by about 20% in the homozygous mutant and simultaneously increases the mass-specific metabolic rate by about 20%. Both effects might be expected to lead to a change in longevity. To test such expectations, the life span of male and female hamsters from three genotypes (wild-type, heterozygous, and homozygous tau mutants, all derived from heterozygote crosses to randomize the genetic background) was recorded in constant darkness. Male hamsters lived significantly longer than females: the overall average life span was 96.9 weeks (SE = 2.5, n = 118) for males and 82.0 weeks (SE = 2.1, n = 99) for females. To our surprise, male and female homozygous mutant hamsters lived significantly longer rather than shorter compared to wild-types. For males, the difference between the two genotypes was on average 14%; for females, the difference was 16%. The mortality rate of wild-type males was significantly different from that of homozygous tau males but not different from that of heterozygotes. Overall, survival of wild-type females was statistically distinguishable from both heterozygous and homozygous mutant females. Male and female wild-type hamsters were heavier than homozygote mutants throughout the entire life span, and heterozygous mutants had intermediate weights. There was no correlation between body mass and life span, and the causes of the extended life span in tail mutant hamsters remain unresolved.