Postnatal maternal separation enhances tonic GABA current of cortical layer 5 pyramidal neurons in juvenile rats and promotes genesis of GABAergic neurons in neocortical molecular layer and subventricular zone in adult rats
Postnatal maternal separation enhances tonic GABA current of cortical layer 5 pyramidal neurons in juvenile rats and promotes genesis of GABAergic neurons in neocortical molecular layer and subventricular zone in adult rats
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产后母体分离增强幼年大鼠皮质5层锥体神经元的强直GABA电流，促进成年大鼠新皮质分子层和室下区GABA能神经元的发生
DOI：
10.1016/j.bbr.2013.11.040
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发表时间：
2014-03-01
影响因子：
2.7
通讯作者：
Jiang, Kewen
中科院分区：
文献类型：
--
作者：
Feng, Mei;Sheng, Guoxia;Jiang, Kewen
产后母亲分离（PMS）已被证明与成年后精神疾病的脆弱性增加有关。然而，其潜在的神经机制尚未得到很好的理解。在这里，我们评估其对皮层第5层（L5）锥体神经元的神经发生和紧张性GABA电流的影响。PMS不仅能促进成年大鼠脑室下区、皮质第1层和海马齿状回的细胞增殖，而且能促进新生细胞向GABA能神经元分化，PMS后5d内新生细胞存活中GABA能神经元比例较高。此外，PMS增加皮层L5锥体细胞P7-10和P30-35的紧张性电流。我们的结果表明，新产生的GABA能神经元和低GABA浓度激活的紧张性电流可能参与PMS后精神障碍的发展。(C)2013爱思唯尔有限公司版权所有。
Postnatal maternal separation (PMS) has been shown to be associated with an increased vulnerability to psychiatric illnesses in adulthood. However, the underlying neurological mechanisms are not well understood. Here we evaluated its effects on neurogenesis and tonic GABA currents of cortical layer 5 (L5) pyramidal neurons. PMS not only increased cell proliferation in the subventricular zone, cortical layer 1 and hippocampal dentate gyrus in the adult brain, but also promoted the newly generated cells to differentiate into GABAergic neurons, and PMS adult brain maintained higher ratios of GABAergic neurons in the survival of newly generated cells within 5 days immediately post PMS. Additionally, PMS increased the tonic currents at P7-10 and P30-35 in cortical L5 pyramidal cells. Our results suggest that the newly generated GABAergic neurons and the low GABA concentration-activated tonic currents may be involved in the development of psychiatric disorders after PMS. (C) 2013 Elsevier B.V. All rights reserved.