Enhanced blood pressure variability in a high cardiovascular risk group of African Americans: FIT4Life Study.
Enhanced blood pressure variability in a high cardiovascular risk group of African Americans: FIT4Life Study.
复制标题
DOI：
10.1016/j.jash.2010.04.005
复制
发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Brown MD
中科院分区：
文献类型：
--
作者：
Veerabhadrappa P;Diaz KM;Feairheller DL;Sturgeon KM;Williamson S;Crabbe DL;Kashem A;Ahrensfield D;Brown MD
非裔美国人的高血压水平会引发血管炎症，导致血管重塑。血压变异性(BPV)与靶器官损害相关。我们的目的是研究炎性标志物与非裔美国人BPV之间的关系。36名非裔美国人接受24小时动态血压监测(ABPM)。用平均真实变异性(ARV)指数计算BPV。空腹采血检测超敏C反应蛋白、肿瘤坏死因子-α和白细胞计数。在调整了年龄、体重指数和24小时平均血压后，hs-C反应蛋白与24小时收缩变异性(r=0.5；p=0.012)和清醒收缩变异性(r=0.45；p=0.02)显著相关。比较hs-CRP三组间的ABPM变量。在后组分析中，两组间的收缩和舒张期变异性在24小时和清醒时间段有显著差异。肿瘤坏死因子-α和白细胞计数与动态血压无相关性。超敏C反应蛋白与收缩期变异性有关，超敏C反应蛋白水平升高与BPV增大有关。更高的炎症状态会影响收缩压更大范围的波动，这反过来可能会促进非裔美国人靶器官损害的早期进展，而不受绝对血压水平的影响。
High blood pressure (BP) levels in African Americans elicit vascular inflammation resulting in vascular remodeling. BP variability (BPV) correlates with target organ damage. We aimed to investigate the relationship between inflammatory markers and BPV in African Americans. 36 African Americans underwent 24-hr ambulatory BP monitoring (ABPM). BPV was calculated using the average real variability (ARV) index. Fasting blood samples were assayed for high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α) and white blood cell (WBC) count. Significant association between hs-CRP and 24-hr systolic variability (r = 0.50; p = 0.012) and awake systolic variability (r = 0.45; p =0.02) was identified after adjusting for age, BMI and 24-hr mean BP. ABPM variables were compared between the hs-CRP tertile groups. In Post-hoc analysis, there was a significant difference in 24-hr and awake periods for both systolic and diastolic variability among the groups. TNF-α and WBC count showed no associations with ABPM variables. hs-CRP is associated with systolic variability and higher levels of hs-CRP are related with greater BPV. Higher inflammatory status influences wider fluctuations in systolic BP which in turn could facilitate early progression to target organ damage independent of absolute BP levelsin African Americans.
登录
查看更多内容
影响因子：
4.4
作者：
Fiscella, Kevin;Holt, Kathleen
通讯作者：
Holt, Kathleen
影响因子：
8.3
作者：
Mancia, Giuseppe;Bombelli, Michele;Sega, Roberto
通讯作者：
Sega, Roberto
影响因子：
1.3
作者：
Parati, G;Bilo, G;Mancia, G
通讯作者：
Mancia, G
DOI：
10.1080/01639360802633938
发表时间：
2009-01-01
期刊：
Journal of Nutrition for the Elderly
影响因子：
--
作者：
Bowman, Shanthy A.
通讯作者：
Bowman, Shanthy A.
DOI：
10.1152/ajpheart.1996.271.4.h1555
发表时间：
1996-10-01
影响因子：
4.8
作者：
Blaber, AP;Bondar, RL;Freeman, R
通讯作者：
Freeman, R