Differential expression of β2-integrins and cytokine production between γδ and αβ T cells in experimental autoimmune encephalomyelitis
Differential expression of β2-integrins and cytokine production between γδ and αβ T cells in experimental autoimmune encephalomyelitis
复制标题
实验性自身免疫性脑脊髓炎中γδ和αβ T 细胞之间β2-整合素的差异表达和细胞因子的产生
DOI：
10.1189/jlb.0407263
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发表时间：
2008-01-01
影响因子：
5.5
通讯作者：
Barnum, Scott R.
中科院分区：
文献类型：
--
作者：
Smith, Sherry S.;Barnum, Scott R.
在幼小鼠或实验性自身免疫性脑脊髓炎(EAE)小鼠的Gamma Delta T细胞上，β(2)整合素的表达仍然很少。我们比较了在EAE急性病程中，β(2)-整合素的表达和细胞因子在γ-β和α-βT细胞中的产生。我们观察到，与α-βT细胞不同，β(2)-整合素在α-βT细胞上的表达从基线开始显著增加，在第10天达到峰值，在引流淋巴结中保持不变，或在第15天在脾和中枢神经系统中下降。此外，在整个EAE过程中，产生干扰素-γ和肿瘤坏死因子-α的γ-βT细胞迅速渗透到中枢神经系统，并产生明显多于α-βT细胞的细胞因子。这些结果表明，β(2)-整合素在EAE期间伽马-β-T细胞与阿尔法-贝塔T细胞的运输中扮演着独特的角色，伽马-βT细胞迅速渗透到中枢神经系统，产生调节急性疾病的细胞因子。
The expression of beta(2)-integrins on gamma delta T cells in naive mice or those with experimental autoimmune encephalomyelitis (EAE) remains poorly characterized. We compared beta(2)-integrin expression and cytokine production between gamma delta and alpha beta T cells over the acute course of EAE. We observed that unlike in alpha beta T cells, beta(2)-integrin expression on gamma delta T cells increased significantly from baseline, peaked at Day 10, and remained unchanged in the draining lymph nodes or declined in the spleen and CNS by Day 15. In addition, IFN-gamma- and TNF-alpha-producing gamma delta T cells infiltrated the CNS rapidly and produced significantly more of these cytokines than alpha beta T cells throughout the course of EAE. These results suggest unique roles for beta(2)-integrins in the trafficking of gamma delta versus alpha beta T cells during EAE and that gamma delta T cells infiltrate the CNS rapidly, producing cytokines, which modulate acute disease.