Elevated Linezolid Resistance in Clinical cfr-Positive Staphylococcus aureus Isolates Is Associated with Co-Occurring Mutations in Ribosomal Protein L3
Elevated Linezolid Resistance in Clinical cfr-Positive Staphylococcus aureus Isolates Is Associated with Co-Occurring Mutations in Ribosomal Protein L3
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DOI：
10.1128/aac.00714-10
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发表时间：
2010-12-01
影响因子：
4.9
通讯作者：
Stein, Jeffrey L.
中科院分区：
文献类型：
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作者：
Locke, Jeffrey B.;Morales, Gracia;Stein, Jeffrey L.
对利奈唑胺 (LZD) 的耐药性是通过 23S rRNA 和核糖体蛋白 L3 和 L4 的突变或通过 Cfr 对 23S rRNA 的甲基化而发生的。在这里，我们报告了新的 L3 突变，Delta Ser145/His146Tyr 和 Delta Met169-Gly174，它们与从西班牙马德里医院暴发中恢复的 LZD 抗性金黄色葡萄球菌分离株中的 CFR 共同发生。 LZD MIC 值（16、32 或 64 μg/ml）与 L3 突变的存在和严重程度相关。所有分离株的 TR-700（托唑胺）MIC 值为
Resistance to linezolid (LZD) occurs through mutations in 23S rRNA and ribosomal proteins L3 and L4 or through methylation of 23S rRNA by Cfr. Here we report novel L3 mutations, Delta Ser145/His146Tyr and Delta Met169-Gly174, co-occurring with cfr in LZD-resistant Staphylococcus aureus isolates recovered from a hospital outbreak in Madrid, Spain. LZD MIC values (16, 32, or 64 mu g/ml) correlated with the presence and severity of the L3 mutation. All isolates had TR-700 (torezolid) MIC values of