A case of frontal neuropsychological and neuroimaging signs following multiple primary-blast exposure
A case of frontal neuropsychological and neuroimaging signs following multiple primary-blast exposure
复制标题
DOI：
10.1080/13554794.2011.588181
复制
发表时间：
2012-01-01
期刊：
影响因子：
0.8
通讯作者：
Tupler, Larry A.
中科院分区：
文献类型：
--
作者：
Hayes, Jasmeet Pannu;Morey, Rajendra A.;Tupler, Larry A.
阿富汗和伊拉克战争中与爆炸相关的创伤性脑损伤（TBI）对军队和退伍军人来说是一个重大的医疗问题。为了更好地了解初次爆炸对人类造成的伤害，我们介绍了一名海军陆战队员在其 14 年的军事生涯中多次遭受初次爆炸的案例。这位以前的高功能退伍军人的神经心理学特征表明主要是执行功能障碍。与来自没有 TBI 的资深参考对照组的复合分数各向异性模板相比，扩散张量成像揭示了长纤维轨迹中的白质病理学。这项研究支持人类存在原发性冲击波诱发的神经创伤，并引入了一种具有区分多发性冲击波 TBI 潜力的神经影像技术。
Blast-related traumatic brain injury (TBI) from the Afghanistan and Iraq wars represents a significant medical concern for troops and veterans. To better understand the consequences of primary-blast injury in humans, we present a case of a Marine exposed to multiple primary blasts during his 14-year military career. The neuropsychological profile of this formerly high-functioning veteran suggested primarily executive dysfunction. Diffusion-tensor imaging revealed white-matter pathology in long fiber tracks compared with a composite fractional-anisotropy template derived from a veteran reference control group without TBI. This study supports the existence of primary blast-induced neurotrauma in humans and introduces a neuroimaging technique with potential to discriminate multiple-blast TBI.