V1 spinal neurons regulate the speed of vertebrate locomotor outputs
V1 spinal neurons regulate the speed of vertebrate locomotor outputs
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DOI：
10.1038/nature04545
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发表时间：
2006-03-09
期刊：
影响因子：
64.8
通讯作者：
Goulding, M
中科院分区：
文献类型：
--
作者：
Gosgnach, S;Lanuza, GM;Goulding, M
产生脊椎动物运动（例如行走和游泳）的神经元网络嵌入脊髓中(1-3)。这些网络被称为中央模式生成器（CPG），是确定神经元集合如何生成简单行为输出的理想系统。尽管人们努力解决步行动物中运动 CPG 的组织问题 (2,4-6)，但对这些运动网络中贡献的脊髓中间神经元细胞类型的身份和功能知之甚少。在这里，我们使用四种互补的遗传方法来直接解决小鼠 V1 神经元的功能，V1 神经元是一类选择性表达转录因子 Engrailed1 的局部电路抑制性中间神经元。我们的结果表明，V1 神经元在运动过程中塑造运动输出，并且是产生“快速”运动爆发所必需的。这些发现概述了抑制在调节运动 CPG 节律频率中的重要作用，并且还表明 V1 神经元在控制脊椎动物运动速度方面可能具有进化上保守的作用。
The neuronal networks that generate vertebrate movements such as walking and swimming are embedded in the spinal cord(1-3). These networks, which are referred to as central pattern generators (CPGs), are ideal systems for determining how ensembles of neurons generate simple behavioural outputs. In spite of efforts to address the organization of the locomotor CPG in walking animals(2,4-6), little is known about the identity and function of the spinal interneuron cell types that contribute to these locomotor networks. Here we use four complementary genetic approaches to directly address the function of mouse V1 neurons, a class of local circuit inhibitory interneurons that selectively express the transcription factor Engrailed1. Our results show that V1 neurons shape motor outputs during locomotion and are required for generating 'fast' motor bursting. These findings outline an important role for inhibition in regulating the frequency of the locomotor CPG rhythm, and also suggest that V1 neurons may have an evolutionarily conserved role in controlling the speed of vertebrate locomotor movements.