Cerebrovascular reactivity in major depression: A pilot study
Cerebrovascular reactivity in major depression: A pilot study
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DOI：
10.1097/01.psy.0000107880.03026.54
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发表时间：
2004-01-01
影响因子：
3.3
通讯作者：
Hartmann, A
中科院分区：
文献类型：
--
作者：
Neu, P;Schlattmann, P;Hartmann, A
目的：越来越多的研究表明抑郁症可能增加脑卒中的危险性。然而，很少有人知道这种关联背后的病理生理机制。脑血管反应性（CVR）反映了脑小动脉对扩张刺激的代偿性扩张能力，是维持脑血流稳定的重要机制。我们假设CVR在重度抑郁症患者中降低，从而有助于抑郁症和卒中之间的关联。研究方法：我们通过计算乙酰唑胺刺激后脑血流速度的增加来评估33例单相抑郁症患者和26例健康对照者的CVR。经颅多普勒超声检测血流速度。结果：抑郁症患者脑血管反应性明显降低。吸烟也与CVR的显著降低相关，而年龄和性别没有显著影响。结论：抑郁症患者的脑血管反应性受损。进一步的研究应阐明导致CVR降低的机制。
Objective: There are a growing number of reports that depression may increase the risk of stroke. Little is known, however, about the pathophysiologic mechanisms underlying this association. Cerebrovascular reactivity (CVR) reflects the compensatory dilatory capacity of cerebral arterioles to a dilatory stimulus and is an important mechanism to provide constant cerebral blood flow. We hypothesized that CVR is reduced in patients with major depression, thus contributing to the association between depression and stroke. Methods: We assessed CVR in 33 patients with unipolar depression and 26 healthy controls by calculating the increase in cerebral blood flow velocity after stimulation with acetazolamide. Blood flow velocities were measured by transcranial Doppler ultrasound. Results: Cerebrovascular reactivity was significantly reduced in depressed patients. Smoking was also associated with a significant reduction in CVR, whereas age and gender had no significant influence. Conclusions: Cerebrovascular reactivity appears to be impaired in major depression. Further studies should clarify the mechanisms leading to this reduced CVR.