Hypoxia-Sensitive Fluorescent Probes for in Vivo Real-Time Fluorescence Imaging of Acute Ischemia
Hypoxia-Sensitive Fluorescent Probes for in Vivo Real-Time Fluorescence Imaging of Acute Ischemia
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DOI：
10.1021/ja105937q
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发表时间：
2010-11-17
影响因子：
15
通讯作者：
Nagano, Tetsuo
中科院分区：
文献类型：
--
作者：
Kiyose, Kazuki;Hanaoka, Kenjiro;Nagano, Tetsuo
基于偶氮官能团作为缺氧传感器部分具有优异性能的研究结果，我们开发了缺氧敏感的近红外荧光探针，其中通过偶氮键的断裂引发大的荧光增加。该探针用于缺氧细胞的荧光成像和实时监测活小鼠肝脏和肾脏的缺血。
Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.