Increased IgE serum levels are unrelated to allergic and parasitic diseases in patients with juvenile systemic lupus erythematosus.
Increased IgE serum levels are unrelated to allergic and parasitic diseases in patients with juvenile systemic lupus erythematosus.
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DOI：
10.6061/clinics/2012(11)09
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Carneiro-Sampaio M
中科院分区：
文献类型：
--
作者：
Liphaus BL;Jesus AA;Silva CA;Coutinho A;Carneiro-Sampaio M
本研究的目的是评估青少年系统性红斑狼疮患者的IgE血清水平，并评估其与临床和实验室特征、疾病活动性和组织损伤的可能关联。用浊度法测定了69例连续发生的幼年系统性红斑狼疮患者的血清IgE浓度。免疫比浊法检测IgG、IgM和IgA浓度。所有患者肠道寄生虫检测均为阴性。统计分析方法包括Mann-Whitney检验、卡方检验和Fisher精确检验，以及Spearman秩相关系数。在31/69（45%）的幼年系统性红斑狼疮患者中，IgE浓度高于100 IU/mL。平均IgE浓度为442.0±163.4 IU/ml （3.5 ~ 9936.0 IU/ml）。69例患者中有15例患有特应性疾病，9例患有严重败血症，56例出现肾炎。54例无特应性表现的少年系统性红斑狼疮患者的平均IgE水平为271.6±699.5 IU/ml， 31例高IgE患者中仅有9例（29%）发生特应性疾病。IgE水平与特应性疾病、严重败血症、肾炎、疾病活动性或组织损伤的存在没有统计学差异。有趣的是，IgE浓度与C4水平呈负相关（r = -0.25, p = 0.03），与SLICC/ACR-DI评分呈负相关（r = -0.34, p = 0.005）。IgE浓度也与IgA水平直接相关（r = 0.52, p = 0.03）。本研究首次证实幼年系统性红斑狼疮患者血清中IgE水平升高。这种IgE水平的增加与过敏性疾病或寄生虫病无关。我们的结果与假设一致，即高IgE水平可以被认为是免疫失调的标志。
The aim of this study was to assess the IgE serum levels in juvenile systemic lupus erythematosus patients and to evaluate possible associations with clinical and laboratory features, disease activity and tissue damage. The IgE serum concentrations in 69 consecutive juvenile systemic lupus erythematosus patients were determined by nephelometry. IgG, IgM and IgA concentrations were measured by immunoturbidimetry. All patients were negative for intestinal parasites. Statistical analysis methods included the Mann-Whitney, chi-square and Fisher's exact tests, as well as the Spearman rank correlation coefficient. Increased IgE concentrations above 100 IU/mL were observed in 31/69 (45%) juvenile systemic lupus erythematosus patients. The mean IgE concentration was 442.0±163.4 IU/ml (range 3.5-9936.0 IU/ml). Fifteen of the 69 patients had atopic disease, nine patients had severe sepsis and 56 patients presented with nephritis. The mean IgE level in 54 juvenile systemic lupus erythematosus patients without atopic manifestations was 271.6±699.5 IU/ml, and only nine of the 31 (29%) patients with high IgE levels had atopic disease. The IgE levels did not statistically differ with respect to the presence of atopic disease, severe sepsis, nephritis, disease activity, or tissue damage. Interestingly, IgE concentrations were inversely correlated with C4 levels (r = -0.25, p = 0.03) and with the SLICC/ACR-DI score (r = -0.34, p = 0.005). The IgE concentration was also found to be directly correlated with IgA levels (r = 0.52, p = 0.03). The present study demonstrated for the first time that juvenile systemic lupus erythematosus patients have increased IgE serum levels. This increase in IgE levels was not related to allergic or parasitic diseases. Our results are in line with the hypothesis that high IgE levels can be considered a marker of immune dysregulation.
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影响因子：
27.4
作者：
Morton, S;Palmer, B;Powell, RJ
通讯作者：
Powell, RJ
影响因子：
9.1
作者：
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影响因子：
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作者：
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影响因子：
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影响因子：
27.4
作者：
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通讯作者：
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