Chronic prostatitis and comorbid non-urological overlapping pain conditions: A co-twin control study.
Chronic prostatitis and comorbid non-urological overlapping pain conditions: A co-twin control study.
复制标题
慢性前列腺炎和共病非泌尿系统重叠疼痛状况：一项双胞胎对照研究。
DOI：
10.1016/j.jpsychores.2017.09.005
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发表时间：
2017
影响因子：
4.7
通讯作者：
Afari,Niloofar
中科院分区：
文献类型：
--
作者：
Gasperi,Marianna;Krieger,JohnN;Forsberg,Christopher;Goldberg,Jack;Buchwald,Dedra;Afari,Niloofar
目的慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）在没有明显感染或其他原因的情况下，以疼痛和排尿症状为特征。CP/CPPS常与病因不明的非泌尿系统慢性重叠性疼痛（COPCs）一起发生。我们对患有慢性前列腺炎（CP）的男性进行了一项双胞对照研究，其中约90%的总体诊断为CP/CPPS。主要目的是调查家族因素，包括共同的遗传和共同的环境因素，对CP和COPCs合并症的贡献。方法研究越南时代双胞胎登记处6824名男性双胞胎的数据，以评估自我报告的终身医生诊断CP与COPCs（包括纤维肌痛、慢性疲劳综合征、肠易激综合征、颞下颌紊乱、紧张性头痛和偏头痛）之间的关系。使用随机效应逻辑回归模型和配对内分析评估家族因素对相关性的混杂效应。结果CP与6种COPCs均有显著相关性。在对双胞胎分析中共同的家族影响进行调整后，所有COPCs的相关性减弱，但仍然显著。家族混杂对CP与纤维肌痛和颞下颌紊乱的相关性最强，对肠易激综合征的相关性最小。结论scp与COPCs合并症高。这些关联可以部分地用家族因素来解释。这些关系背后的机制可能是多种多样和多因素的。未来的纵向研究有助于进一步阐明特定的遗传和环境机制，并确定CP与其合并症之间的潜在因果关系。
ObjectivesChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is characterized by pain and voiding symptoms in the absence of an obvious infection or other cause. CP/CPPS frequently occurs with non-urological chronic overlapping pain conditions (COPCs) of unknown etiology. We conducted a co-twin control study in men discordant for chronic prostatitis (CP), an overarching diagnosis of which approximately 90% is CP/CPPS. The primary aim was to investigate the contribution of familial factors, including shared genetic and common environmental factors, to the comorbidity of CP and COPCs.MethodsData from 6824 male twins in the Vietnam Era Twin Registry were examined to evaluate the association between self-reported lifetime physician diagnosis of CP with COPCs including fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, temporomandibular disorder, tension headaches, and migraine headaches. Random effects logistic regression models were used and within-pair analyses evaluated confounding effects of familial factors on the associations.ResultsThere were significant associations between CP and all 6 examined COPCs. After adjusting for shared familial influences in within twin pair analyses, the associations for all COPCs diminished but remained significant. Familial confounding was strongest for the association of CP with fibromyalgia and temporomandibular disorder and smallest for irritable bowel syndrome.ConclusionsCP and COPCs are highly comorbid. These associations can be partially explained by familial factors. The mechanisms underlying these relationships are likely diverse and multifactorial. Future longitudinal research can help to further elucidate specific genetic and environmental mechanisms and determine potentially causal relationships between CP and its comorbidities.