The ADP-ATP Carrier in Mitochondrial Membranes

The ADP-ATP Carrier in Mitochondrial Membranes
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线粒体膜中的 ADP-ATP 载体

DOI:
10.1007/978-1-4684-2658-8_15
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发表时间:
1976
影响因子:
2.3
通讯作者:
M. Klingenberg
M. Klingenberg
中科院分区:
医学3区
文献类型:
--
作者:
M. Klingenberg

文献摘要

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已知线粒体内膜含有许多与氧化和磷酸化反应相关的膜结合酶。在过去的十年中,已经发现该膜还促进了许多代谢物的特异性转运,这些代谢物在线粒体的代谢途径中充当中间体。特别突出的是与三羧酸循环、转氨反应以及氧化磷酸化和底物水平磷酸化中的磷酸转移反应相关的代谢物(综述见Klingenberg,1970; Meijer和货车Dam,1974; LaNoue和Schoolwerth,1979; Scarpa,1979)。
The inner mitochondrial membrane is known to contain a number of membrane-bound enzymes which are linked to oxidation and phosphorylation reactions. During the past ten years, it has been found that this membrane also facilitates the specific transport of a number of metabolites which function as intermediates in metabolic pathways of mitochondria. Particularly prominent are the metabolites associated with the tricar-boxylic acid cycle, with transamination reactions, and with phosphate transfer reactions in oxidative and substrate-level phosphorylation (for reviews, see Klingenberg, 1970; Meijer and van Dam, 1974; LaNoue and Schoolwerth, 1979; Scarpa, 1979).