Analysis of HLA-DM polymorphisms in sarcoidosis
Analysis of HLA-DM polymorphisms in sarcoidosis
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DOI：
10.1016/0198-8859(96)82496-7
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发表时间：
1996-09-01
期刊：
影响因子：
2.7
通讯作者：
Inoko, H
中科院分区：
文献类型：
--
作者：
Ishihara, M;Naruse, T;Inoko, H
结节病是一种多系统性肉芽肿性疾病，显示HLA-DRB*11显著增加。日本人群中的 *12、*14和 *08等位基因。为了评价DMA和DMB基因多态性在结节病易感性中的作用，采用PCR-RFLP方法分析了70例日本结节病患者和95例无关健康对照者的DMA和DMB基因第三外显子多态性。DMA等位基因的分布在患者组和对照组之间没有差异。与健康对照组相比，患者组DMB*0102频率增高（p < 0.05），DMB*0101频率降低（p < 0.05）。然而，这种关联和负关联可以用与疾病相关的DRB 1等位基因的连锁不平衡来解释。DMA和DMB基因并不主要赋予结节病的易感性。
Sarcoidosis is a multisystemic granulomatous disorder showing significant increases in the HLA-DRB*11. *12, *14 and *08 alleles in the Japanese population. To evaluate the role of polymorphism in the DMA and DMB genes in predisposition to sarcoidosis, seventy Japanese patients with sarcoidosis and 95 unrelated healthy controls were analyzed in the third exon polymorphisms within the DMA and DMB genes by the PCR-RFLP method. There were no differences in the distribution of DMA alleles between the patient and control groups. The frequency of DMB*0102 was higher (p < 0.05) and that of DMB*0101 was lower (p < 0.05) in the patients than in the healthy controls. However, this association and negative association could be explained by linkage disequilibrium with the disease-associated DRB1 alleles. The DMA and DMB genes do not primarily confer the susceptibility to sarcoidosis.