Comparative effects and metabolism of two microcystins and nodularin in the brine shrimp Artemia salina
Comparative effects and metabolism of two microcystins and nodularin in the brine shrimp Artemia salina
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DOI：
10.1016/s0166-445x(02)00091-7
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发表时间：
2003-02-12
影响因子：
4.5
通讯作者：
Pflugmacher, S
中科院分区：
文献类型：
--
作者：
Beattie, KA;Ressler, J;Pflugmacher, S
以卤虫（Artemia salina）为材料，研究了藻毒素微囊藻毒素（Microcystin-LR，MclA）、Dhb-Microcystin-HtyR和节球藻毒素（nodularin）对卤虫包囊、无节幼体和成体的毒性和代谢。使用不同的底物显示了在这些阶段中存在第11阶段解毒系统谷胱甘肽S-转移酶（sGST）。成人A的暴露。盐藻对毒素的作用导致体内GST活性升高。所有三种毒素通过GST与谷胱甘肽缀合，这已被证明是微囊藻毒素和节球藻毒素解毒的初始步骤。(C)2002 Elsevier Science B. V.保留所有权利。
The toxicity and metabolism of the cyanobacterial toxins microcystin-LR (MCLR), Dhb-microcystin-HtyR and nodularin were investigated in the cysts, nauplii and adults of the brine shrimp Artemia salina. The presence of the phase 11 detoxication system glutathione S-transferase (sGST) in these stages was shown using different substrates. Exposure of adult A. salina to the toxins led to an elevation of GST activity in vivo. All three toxins were conjugated to glutathione via GST, which has been shown as an initial step of microcystin and nodularin detoxication. (C) 2002 Elsevier Science B.V. All rights reserved.