Reduction of cerebrospinal fluid amyloid β after systemic administration of M1 muscarinic agonists
Reduction of cerebrospinal fluid amyloid β after systemic administration of M1 muscarinic agonists
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DOI：
10.1016/s0006-8993(01)02484-2
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发表时间：
2001-06-29
期刊：
影响因子：
2.9
通讯作者：
Fisher, A
中科院分区：
文献类型：
--
作者：
Beach, TG;Walker, DG;Fisher, A
淀粉样肽β（A β）的过度产生是阿尔茨海默病（AD）的关键事件。全身给予3种M1-选择性毒蕈碱激动剂AF 102 B、AF 150 S和AF 267 B，降低了脑脊液（CSF）A β浓度; CSF分泌的β-APP水平没有显著改变。用s.c.注射每种药物（2 mg/kg/天）的CSF A β水平为A β 1-40对照的55 - 71%，A β 1-42对照的59 - 84%。(C)2001 Elsevier Science B. V.保留所有权利。
Overproduction of the peptide amyloid beta (A beta) is a critical event in Alzheimer's disease (AD). Systemic administration of 3 Mi-selective muscarinic agonists, AF102B, AF150S and AF267B, decreased cerebrospinal fluid (CSF) A beta concentrations; levels of CSF secreted beta -APP were not significantly altered. Rabbits treated for 5 days with s.c. injections of each drug (2 mg/kg/day) had levels of CSF A beta which were between 55 and 71% of control for A beta 1-40 and between 59 and 84% of control for A beta 1-42. (C) 2001 Elsevier Science B.V. All rights reserved.