Modality-specific sensory changes in humans after the induction of long-term potentiation (LTP) in cutaneous nociceptive pathways
Modality-specific sensory changes in humans after the induction of long-term potentiation (LTP) in cutaneous nociceptive pathways
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DOI：
10.1016/j.pain.2006.09.026
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发表时间：
2007-04-01
期刊：
影响因子：
7.4
通讯作者：
Treede, Rolf-Detlef
中科院分区：
文献类型：
--
作者：
Lang, Stefanie;Klein, Thomas;Treede, Rolf-Detlef
通过12例健康人前臂腹侧定量感觉测试（QST），研究了伤害性通路的长时程增强（LTP）对体感觉知觉的影响。前臂皮肤的高频电刺激（HFS; 5 x 1 s, 100 Hz， 10倍检测阈值）导致通过同一电极施加的单一电测试刺激的疼痛突然增加（知觉LTP +72% p < 0.01）。知觉LTP持续时间超过1小时的观察期。HFS对条件皮肤区域自然测试刺激的体感觉知觉的影响仅限于机械亚模。针刺刺激能显著降低疼痛阈值，提高疼痛等级（p < 0.01）。12名受试者中有5名（42%）轻触觉刺激导致疼痛感觉（动态机械异常性疼痛）。此外，钝性压力刺激阈值虽小但显著降低（p < 0.05）。相比之下，所有的热模态，包括冷和热检测阈值，冷和热疼痛阈值以及疼痛总和（感知wind up）保持不变。这些数据表明，肽能性皮肤c纤维传入神经的HFS主要调节A -和A - β纤维介导的体感觉功能，表明伤害性通路中的LTP通过两种传入通路的相互作用（外源性致敏）增强人的疼痛敏感性。(c) 2006国际疼痛研究协会。Elsevier B.V.版权所有。
The impact of long-term potentiation (LTP) in nociceptive pathways on somatosensory perception was examined by means of quantitative sensory testing (QST) in the ventral forearm of 12 healthy human subjects. Electrical high-frequency stimulation of the forearm skin (HFS; 5 x 1 s at 100 Hz and 10 x detection threshold) led to an abrupt increase of pain to single electrical test stimuli, which were applied through the same electrode (perceptual LTP +72% p < 0.01). Perceptual LTP outlasted the 1-h observation period. The effects of HFS on somatosensory perception of natural test stimuli in the conditioned skin area were restricted to mechanical submodalities. Subjects exhibited a significant decrease of pain threshold and an increase of pain ratings to suprathreshold pinprick stimuli (p < 0.01). In 5 out of 12 subjects (42%) light tactile stimuli led to painful sensations (dynamic mechanical allodynia). Furthermore, a small but significant decrease of threshold to blunt pressure stimuli (p < 0.05) was found. In contrast, all thermal modalities comprising cold and warm detection thresholds, cold and heat pain thresholds as well as pain summation (perceptual wind up) remained unaltered. These data show that HFS of peptidergic cutaneous C-fiber afferents predominantly modulates A delta- and A beta-fiber mediated somatosensory functions, suggesting that LTP in nociceptive pathways enhances human pain sensitivity via interaction of two afferent pathways (extrinsic sensitization). (c) 2006 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.