UROTHELIAL PROLIFERATION IN GROWING MICE
UROTHELIAL PROLIFERATION IN GROWING MICE
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DOI：
10.1111/j.1365-2184.1986.tb00725.x
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发表时间：
1986-03-01
期刊：
影响因子：
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通讯作者：
POTTEN, CS
中科院分区：
文献类型：
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作者：
JOST, SP;POTTEN, CS
发育中的小鼠尿路上皮在出生后至少10天内会经历明显的增殖。此后，随着年龄的增长，有丝分裂和[3H] tdr标记指数均急剧下降。在发育过程中，标记与有丝分裂指数的比例也发生了显著变化，这可能是由于内复制和DNA合成和有丝分裂阶段的相对持续时间的变化。这一比例在5周龄时达到稳定。成虫标记指数和有丝分裂指数分别为0.11和0.019%，表明其更替非常缓慢。
Developing murine urothelium undergoes pronounced proliferation until at least 10 days after birth. Thereafter, both mitotic and [3H]TdR-labelling indices fall sharply with age. The ratio of labelling to mitotic indices also alters dramatically during development, which is probably due to both endoreduplication and changes in the relative durations of the DNA synthesis and mitotic phases. This ratio reaches stability at 5 weeks of age. The adult labelling and mitotic indices were 0.11 and 0.019% respectively, indicating a very slow turnover.