Collection of sibling donor cord blood for children with thalassemia.
Collection of sibling donor cord blood for children with thalassemia.
复制标题
为患有地中海贫血的儿童收集兄弟姐妹捐赠的脐带血。
DOI：
10.1097/00043426-200011000-00031
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Lubin,BH
中科院分区：
文献类型：
--
作者：
Reed,W;Walters,M;Lubin,BH
骨髓移植对有匹配同胞骨髓供者的重型地中海贫血患者具有治疗潜力，但替代干细胞来源的有效性正在调查中。来自同胞的脐带血（CB）具有与骨髓不同的特性，作为干细胞来源具有潜在的优点和缺点。虽然许多家庭照顾患有重型地中海贫血（或其他移植可治疗的疾病）的孩子会经历额外的怀孕，但大多数人在医院分娩，而没有收集和处理新生儿CB所需的基础设施。为了解决这个问题，在美国国立卫生研究院的资助下，我们开发了第一个非商业性的CB计划，在美国各地运作，专门用于促进从兄弟姐妹捐赠者那里收集医学上有指征的CB。使用的情况下，管理模式，我们已经收集了CB的25地中海贫血家族在8个州。其中三个CB单位现已用于移植;另外两个是人类白细胞抗原相同的，并含有足够的有核细胞剂量，以在其预期的受体中进行移植。我们的结论是，CB银行专注于兄弟姐妹捐赠可能是一个有用的干细胞资源，并与特定的医疗需要，如地中海贫血的儿童，家庭应考虑保留CB从兄弟姐妹。
Bone marrow transplantation has curative potential for patients with thalassemia major who have a matched sibling marrow donor, but usefulness of alternative stem cell sources is undergoing investigation. Cord blood (CB) from a sibling has different characteristics from marrow and has potential advantages and disadvantages as a stem cell source. Whereas many families caring for a child with thalassemia major (or other transplant-treatable condition) experience an additional pregnancy, most give birth at hospitals without the infrastructure needed to collect and process the new infant's CB. To address this, and with funding from the National Institutes of Health, we have developed the first noncommercial CB program, operating across the United States, designed specifically to facilitate medically indicated CB collections from sibling donors. Using a case-management model, we have collected CB for 25 thalassemia families in eight states. Three of these CB units have now been used for transplantation; two others are human leukocyte antigen-identical and contain adequate nucleated cell dose to perform transplantation in their intended recipient. We conclude that a CB bank focused on sibling donations may be a useful stem cell resource and that families with specific medical need, such as a child with thalassemia, should consider preserving CB from siblings.