Early high-dose erythropoietin therapy and hypothermia after out-of-hospital cardiac arrest:: A matched control study
Early high-dose erythropoietin therapy and hypothermia after out-of-hospital cardiac arrest:: A matched control study
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DOI：
10.1016/j.resuscitation.2007.10.003
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发表时间：
2008-03-01
期刊：
影响因子：
6.5
通讯作者：
Hermine, Olivier
中科院分区：
文献类型：
--
作者：
Cariou, Alain;Claessens, Yann-Erick;Hermine, Olivier
目的：目的：探讨院外心脏骤停（OHCA）后早期应用大剂量促红细胞生成素-α（Epo-alpha）的神经保护作用。在OHCA后轻度低温复苏后，参与者接受了第一剂Epo-alpha，随后在48小时内进行了四次额外注射（每次注射40，000 IU静脉注射）。在不同时间点测量血浆Epo-alpha水平。结果和不良事件进行了评估，到第28天，并与匹配配对controls.Results：在所有18名参与者接受环氧乙烷-α和40个匹配的对照进行了比较。药代动力学变量与以前报道的健康人或用常规剂量的Epo治疗的人相似。在第28天，Epo治疗组和对照组的存活率（55% vs 47.5%，p = 0.17）和完全神经恢复率（55% vs 37.5%）没有显著差异。血小板增多症的发生率在环氧乙烷治疗组和对照组分别为15%和5%，分别观察到动脉血管血栓形成的情况下（5%）从环氧乙烷治疗cohol.Conclusions：在OHCA的受害者与环氧乙烷-α和低温治疗，我们观察到一个很高的生存率，没有轻微的脑后遗症，但潜在的血液学副作用。未来的Epo研究应特别注意这些发现。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Aim: To test the possible neuroprotective effect of early high-dose erythropoietin-alpha (Epo-alpha) after out-of-hospital cardiac arrest (OHCA).Methods: A matched control study. Following resuscitation with mild hypothermia after OHCA, participants received a first dose of Epo-alpha followed by four additional injections within 48 h (40,000 IU intravenously each injection). Plasma Epo-alpha levels were measured at different time points. Outcome and adverse events were assessed up to day 28 and were compared with those of matched-paired controls.Results: In all 18 participants received Epo-alpha and were compared with 40 matched controls. Pharmacokinetic variables were similar to those previously reported for healthy people or for persons treated with usual dosages of Epo. At day 28, survival rates among the Epo-treated group and the controls (55% versus 47.5%, p = 0.17) and rates of full neurological recovery (55% versus 37.5%) did not differ significantly. Incidences of thrombocytosis in the Epo-treated group and controls were 15% and 5%, respectively; an arterial vascular thrombosis was observed in one case (5%) from the Epo-treated cohort.Conclusions: Among victims of OHCA treated with Epo-alpha and hypothermia, we observed a high survival rate, with no minor cerebral sequels but potential haematological side effects. Future studies of Epo should pay particular attention to these findings. (c) 2007 Elsevier Ireland Ltd. All rights reserved.