A clinicopathologic and immunohistochemical analysis of melanotic neuroectodermal tumor of infancy
A clinicopathologic and immunohistochemical analysis of melanotic neuroectodermal tumor of infancy
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DOI：
10.1067/moe.2002.124000
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发表时间：
2002-06-01
期刊：
影响因子：
--
通讯作者：
Speight, PM
中科院分区：
文献类型：
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作者：
Barrett, AW;Morgan, M;Speight, PM
目标。本研究的目的是回顾8例婴幼儿黑素性神经外胚层肿瘤（MNTI）的特征，包括NB84、CD99、PGP 9.5、特异性细胞角蛋白和Ki-67的表达，这些标志物以前在该肿瘤中没有报道过。研究设计。对8例儿童MNTIs进行了临床病理和免疫组织化学分析。患者年龄为2个半月至14个月。其中7名是男性。上颌有7个病变。显微镜下，将较大的黑色素细胞样细胞与较小的神经母细胞样细胞混合。所有mnti都含有黑色素；虽然大多数表现为细胞异型性，但有丝分裂并不常见(
Objective. The purpose of this study was to review the features of 8 cases of melanotic neuroectodermal tumor of infancy (MNTI) of the jaws with respect to the expression of NB84, CD99, PGP 9.5, specific cytokeratins, and Ki-67, markers not previously reported in this entity.Study design. A clinicopathologic and immunohistochemical analysis of MNTIs in 8 children was undertaken.Results. Patients were aged 21/2 months to 14 months. Seven were males. Seven lesions affected the maxilla. Microscopically, collections of larger, melanocyte-like cells were admixed with smaller, neuroblast-like cells. All MNTIs contained melanin; although most showed cellular atypia, mitoses were infrequent (