Exploring the Source of Neural Responses of Different Latencies Obtained from Different Recording Electrodes in Cochlear Implant Users.
Exploring the Source of Neural Responses of Different Latencies Obtained from Different Recording Electrodes in Cochlear Implant Users.
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DOI：
10.1159/000444739
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发表时间：
2016
影响因子：
1.6
通讯作者：
Abbas PJ
中科院分区：
文献类型：
--
作者：
Kashio A;Tejani VD;Scheperle RA;Brown CJ;Abbas PJ
本研究采用不同记录电极测量耳蜗电诱发复合动作电位（ECAP）。假设不同的反应潜伏期可能是导致反应的神经群体差异的结果，我们评估了神经反应潜伏期和兴奋传播之间的关系。首先，我们评估了记录电极位置变化时N1潜伏期的变化。其次，我们记录通道的相互作用功能，使用前向掩蔽技术，但在不同的耳蜗内位置的记录电极。对于大多数人来说，N1潜伏期在记录电极上是相似的。然而，减少N1潜伏期观察到21%的CI用户时，ECAP记录使用远程记录电极。我们假设，如果来自不同电极的记录代表来自不同神经元群体的贡献，那么人们可能会期望通道相互作用功能会有所不同。然而，我们没有观察到通道相互作用功能的一致差异（无论是峰位置还是功能的宽度），并且通道相互作用功能的任何变化与ECAP潜伏期无关。这些结果表明，来自不同记录电极的具有不同潜伏期的ECAP起源于相似的神经群体。
In this study we measured the electrically evoked compound action potential (ECAP) from different recording electrodes in cochlea. Under the assumption that different response latency may be the result of differences in the neural population contributing to the response, we assessed the relationship between neural response latency and spread of excitation. First, we evaluated changes in N1 latency when the recording electrode site was varied. Second, we recorded channel interaction functions using a forward masking technique but with recording electrodes at different intra-cochlear locations. For most individuals, N1 latency was similar across recording electrodes. However, reduced N1 latencies were observed in 21% of CI users when ECAPs were recorded using a remote recording electrode. We hypothesized that if recordings from different electrodes represented contributions from different populations of neurons, then one might expect that channel interaction functions would be different. However, we did not observe consistent differences in channel interaction functions (neither peak location nor breadth of the functions), and further, any variation in channel interaction functions were not correlated with ECAP latency. These results suggest that ECAPs from different recording electrodes with different latency originate from similar neural populations.