FOS-ASSOCIATED PROTEIN-P39 IS THE PRODUCT OF THE JUN PROTO-ONCOGENE
FOS-ASSOCIATED PROTEIN-P39 IS THE PRODUCT OF THE JUN PROTO-ONCOGENE
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DOI：
10.1126/science.3130660
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发表时间：
1988-05-20
期刊：
影响因子：
56.9
通讯作者：
FRANZA, BR
中科院分区：
文献类型：
--
作者：
RAUSCHER, FJ;COHEN, DR;FRANZA, BR
Fos蛋白复合物和几种Fos相关抗原（FRA）特异性结合称为HeLa细胞激活蛋白1（AP-1）结合位点的序列元件。结合结构和免疫学比较，已确定Fos相关蛋白（p39）为jun原癌基因（c-Jun）的蛋白产物。p39/Jun蛋白是在细胞蛋白的AP-1寡核苷酸亲和层析提取物中鉴定的主要多肽之一。这些AP-1制剂还含有Fos和几种FRA。这些蛋白质中的一些直接结合到AP-1位点，而其他蛋白质，如Fos，似乎通过蛋白质-蛋白质相互作用间接结合。细胞表面刺激导致c-fos和c-jun产物的增加。因此，由细胞外刺激诱导的两种原癌基因（和几种相关蛋白质）的产物形成与含有AP-1位点的转录控制元件相关联的复合物，从而潜在地介导对调节生长控制和发育的信号的长期响应。
The Fos protein complex and several Fos-related antigens (FRA) bind specifically to a sequence element referred to as the HeLa cell activator protein 1 (AP-1) binding site. A combination of structural and immunological comparisons has identified the Fos-associated protein (p39) as the protein product of thejunproto-oncogene (c-Jun). The p39/Jun protein is one of the major polypeptides identified in AP-1 oligonucleotide affinity chromatography extracts of cellular proteins. These preparations of AP-1 also contain Fos and several FRA's. Some of these proteins bind to the AP-1 site directly whereas others, like Fos, appear to bind indirectly via protein-protein interactions. Cell-surface stimulation results in an increase in c-fosand c-junproducts. Thus, the products of two protooncogenes (and several related proteins), induced by extracellular stimuli, form a complex that associates with transcriptional control elements containing AP-1 sites, thereby potentially mediating the long-term responses to signals that regulate growth control and development.