Event-related potential and EEG oscillatory predictors of verbal memory in mild cognitive impairment.
Event-related potential and EEG oscillatory predictors of verbal memory in mild cognitive impairment.
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DOI：
10.1093/braincomms/fcaa213
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发表时间：
2020
影响因子：
4.8
通讯作者：
Olichney JM
中科院分区：
文献类型：
--
作者：
Xia J;Mazaheri A;Segaert K;Salmon DP;Harvey D;Shapiro K;Kutas M;Olichney JM
可靠的记忆力衰退生物标志物对于早期检测阿尔茨海默病至关重要。先前的工作已经发现了三种EEG测量，即事件相关脑电位P600，α频率范围（10 Hz）内振荡活动的抑制以及低θ/高δ和α/β活动之间的交叉频率耦合，其中每一种都与健康老年人和轻度认知障碍或前驱阿尔茨海默病患者的语言学习和记忆能力密切相关。在本研究中，我们解决的问题是否事件相关或振荡的措施，或其组合，最好的预测轻度认知障碍和阿尔茨海默氏病的言语记忆的下降。单次试验相关性分析表明，尽管它们的时间进程和对单词重复的敏感性相似，但P600和α抑制成分在逐个试验的基础上彼此相关性最低（通常|Rs| < 0.10）。这表明它们不太可能源于相同的神经机制。此外，由带通滤波（δ、θ、α、β或γ频带）单次试验数据构建的事件相关脑电位表明，只有δ频带活动（1-4 Hz）与典型P600重复效应强相关（r = 0.94，P < 0.001）;较高频带的事件相关脑电位则不相关。重要的是，逐步多元回归分析表明，三个事件相关的脑电位/振荡措施是互补的预测加州言语学习测试成绩（整体R2的0.45-0.63的范围）。本研究强调了结合EEG事件相关电位和振荡措施的重要性，以更好地表征轻度认知障碍或前驱阿尔茨海默病患者记忆障碍的多种机制。Xia等人发现，将记忆过程的认知事件相关电位（例如P600单词重复效应）和EEG振荡测量（例如α抑制）相结合是互补的，并在包括25名轻度认知障碍或前驱阿尔茨海默病患者的老年队列中产生了言语记忆能力的高度预测模型。
Reliable biomarkers of memory decline are critical for the early detection of Alzheimer’s disease. Previous work has found three EEG measures, namely the event-related brain potential P600, suppression of oscillatory activity in the alpha frequency range (∼10 Hz) and cross-frequency coupling between low theta/high delta and alpha/beta activity, each of which correlates strongly with verbal learning and memory abilities in healthy elderly and patients with mild cognitive impairment or prodromal Alzheimer’s disease. In the present study, we address the question of whether event-related or oscillatory measures, or a combination thereof, best predict the decline of verbal memory in mild cognitive impairment and Alzheimer’s disease. Single-trial correlation analyses show that despite a similarity in their time courses and sensitivities to word repetition, the P600 and the alpha suppression components are minimally correlated with each other on a trial-by-trial basis (generally |rs| < 0.10). This suggests that they are unlikely to stem from the same neural mechanism. Furthermore, event-related brain potentials constructed from bandpass filtered (delta, theta, alpha, beta or gamma bands) single-trial data indicate that only delta band activity (1–4 Hz) is strongly correlated (r = 0.94, P < 0.001) with the canonical P600 repetition effect; event-related potentials in higher frequency bands are not. Importantly, stepwise multiple regression analyses reveal that the three event-related brain potential/oscillatory measures are complementary in predicting California Verbal Learning Test scores (overall R2’s in 0.45–0.63 range). The present study highlights the importance of combining EEG event-related potential and oscillatory measures to better characterize the multiple mechanisms of memory failure in individuals with mild cognitive impairment or prodromal Alzheimer’s disease. Xia et al. found that combining cognitive event-related potential (e.g. P600 word repetition effect) and EEG oscillatory measures (e.g. alpha suppression) of memory processes were complementary and produced highly predictive models of verbal memory abilities in an elderly cohort which included 25 persons with mild cognitive impairment or prodromal Alzheimer’s disease.