Can exercise training with weight loss lower serum C-reactive protein levels?
Can exercise training with weight loss lower serum C-reactive protein levels?
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DOI：
10.1161/01.atv.0000140199.14930.32
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发表时间：
2004-10-01
影响因子：
8.7
通讯作者：
Kitabatake, A
中科院分区：
文献类型：
--
作者：
Okita, K;Nishijima, H;Kitabatake, A
目的C反应蛋白(CRP)是一种肥胖相关的炎症标志物，有望成为心血管疾病的预测指标，并可能成为动脉粥样硬化形成的介质。据报道，饮食诱导的体重减轻会降低CRP水平。然而，另一种可以减肥的疗法--运动训练对C反应蛋白的影响仍不清楚。我们考察了减重运动对C反应蛋白水平和常规心血管风险的影响。方法和结果：共招募了227名看似健康的女性，199名受试者(平均年龄52岁)完成了为期2个月的减重计划，其中包括有监督的有氧运动。治疗后体重由65.8 kg降至62.8 kg(P
Objective - C-reactive protein (CRP), an obesity-related inflammatory marker, is a promising predictor for cardiovascular disease and may be a mediator for atherogenesis. It has been reported that diet-induced weight loss lowered CRP levels. However, the effect of exercise training, another therapy that can reduce weight, on CRP is still unclear. We examined effects of exercise training with weight loss on CRP levels and conventional cardiovascular risks.Methods and Results - A total of 227 apparently healthy women were recruited, and 199 subjects ( average age 52 years) completed a 2-month weight reduction program consisting of supervised aerobic exercises. After the program, weight was reduced from 65.8 to 62.8 kg ( P