Anti-Yo Antibodies in Children With ADHD: First Results About Serum Cytokines
Anti-Yo Antibodies in Children With ADHD: First Results About Serum Cytokines
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DOI：
10.1177/1087054716643387
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发表时间：
2020-09-01
影响因子：
3
通讯作者：
Di Trani, Michela
中科院分区：
文献类型：
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作者：
Donfrancesco, Renato;Nativio, Paola;Di Trani, Michela
目的：研究浦肯野细胞抗体阳性的ADHD儿童是否表现出与高水平细胞因子水平相关的促炎活性。方法：将58例ADHD患者与36名年龄、性别匹配的健康儿童进行比较。45例ADHD儿童抗Yo抗体阳性，34例对照组儿童抗Yo抗体阴性。检测抗Yo抗体阳性ADHD患儿和阴性ADHD患儿血清白介素4(IL-4)、IL-6、IL-10、IL-17、肿瘤坏死因子α(TNF-α)、干扰素-γ(IFN-γ)水平。结果：ADHD组抗-Yo抗体阳性率为77.58%，对照组为22.42%。两组患儿IL-6、IL-10水平差异有统计学意义，ADHD患儿血清细胞因子水平高于对照组。结论：ADHD患儿免疫过程可能与细胞因子等炎症介质有关。这些结果有助于我们理解神经抗体和细胞因子在ADHD中的作用。
Objective:We investigated whether ADHD children who are positive to Purkinje cell antibodies display pro-inflammatory activity associated with high cytokine serum levels.Method:Fifty-eight ADHD outpatients were compared with 36 healthy, age- and sex-matched children. Forty-five of the ADHD children were positive to anti-Yo antibodies, whereas 34 of the control children were negative. Interleukin 4 (IL-4), IL-6, IL-10, IL-17, tumor necrosis factor alpha (TNF alpha), and interferon gamma (IFN gamma) cytokine serum levels were tested in ADHD children who were positive to anti-Yo antibodies and in the control children who were negative.Results:Anti-Yo antibodies were present to a greater extent in the ADHD group: 77.58% versus 22.42%. Significant differences emerged between the two groups in IL-6 and IL-10, with higher cytokine levels being detected in ADHD children than in controls.Conclusion:Immune processes in ADHD are likely to be associated with mediators of inflammation, such as cytokines. These results contribute to our understanding of action of neural antibodies and cytokines in ADHD.