Procedural learning and cognitive flexibility in a mouse model of restricted, repetitive behaviour
Procedural learning and cognitive flexibility in a mouse model of restricted, repetitive behaviour
复制标题
DOI：
10.1016/j.bbr.2008.01.001
复制
发表时间：
2008-06-03
影响因子：
2.7
通讯作者：
Lewis, Mark H.
中科院分区：
文献类型：
--
作者：
Tanimura, Yoko;Yang, Mark C.;Lewis, Mark H.
限制性、重复性行为（例如，刻板、强迫、仪式）与皮质-基底神经节回路的改变有关。由该电路介导的认知过程（例如，程序性学习、执行功能）在表现出高重复率行为的个体中可能受损。为了验证这一假设，我们评估了程序性学习和认知灵活性（逆转学习）使用T-迷宫任务鹿小鼠（Peromyscus maniculatus）表现出不同的重复行为率（垂直跳跃和向后翻筋斗）。这些小鼠在标准啮齿类动物笼中饲养时表现出高比率的刻板行为，并且将它们安置在更大更复杂的环境中会显着减弱这种行为。在复杂环境中饲养的小鼠比标准笼养小鼠表现出显着更好的程序性学习和逆转学习。因此，早期经验与预防和减轻刻板印象与更好的纹状体介导的学习和认知灵活性。刻板印象得分与逆向学习中的错误数显著相关，并与住房条件交互作用，影响整体认知表现。我们的研究结果支持鹿鼠自发刻板行为模型适用于更广泛的限制性重复行为（例如，坚持相同）典型的神经发育障碍。(C)2008 Elsevier B. V.保留所有权利。
Restricted, repetitive behaviours (e.g., stereotypies, compulsions, rituals) in neurodevelopmental disorders have been linked to alterations in cortico-basal ganglia circuitry. Cognitive processes mediated by this circuitry (e.g., procedural learning, executive function) are likely to be impaired in individuals exhibiting high rates of repetitive behaviour. To test this hypothesis, we assessed both procedural learning and cognitive flexibility (reversal learning) using a T-maze task in deer mice (Peromyscus maniculatus) exhibiting various rates of repetitive behaviour (vertical jumping and backward somersaulting). These mice exhibited high rates of stereotypy when reared in standard rodent cages, and such behaviour was significantly attenuated by housing them in larger more complex environments. Mice reared in complex environments exhibited significantly better procedural and reversal learning than standard caged mice. Thus, early experience associated with the prevention and attenuation of stereotypy was associated with better striatally mediated learning and cognitive flexibility. Stereotypy score was significantly correlated with the number of errors made in reversal learning, and interacted with housing condition to affect overall cognitive performance. Our findings support the applicability of the deer mouse model of spontaneous stereotypy to a wider range of restricted, repetitive behaviour (e.g., insistence on sameness) typical of neurodevelopmental disorders. (C) 2008 Elsevier B.V. All rights reserved.