Characterization of cholinergic regulation of seizures by the midline thalamus.
Characterization of cholinergic regulation of seizures by the midline thalamus.
复制标题
中线丘脑对癫痫发作的胆碱能调节的特征。
DOI：
10.1016/0028-3908(92)90067-y
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发表时间：
1992
影响因子：
4.7
通讯作者：
Bardgett,ME
中科院分区：
文献类型：
--
作者：
Miller,JW;Gray,BC;Bardgett,ME
本研究确定了在丘脑中央内侧层内核注射不同胆碱能药物对静脉注射戊四唑引起的癫痫发作的影响。注射胆碱酯酶抑制剂，新斯的明溴化，诱导僵硬，震颤状态和降低肌阵挛，阵挛和强直发作阈值。烟碱激动剂酒石酸尼古丁抑制觉醒并促进所有类型的癫痫发作，而其拮抗剂d-管柯碱氯提高觉醒并转化戊四氮引起的惊厥，强直性癫痫发作发生在一个非常低的阈值，没有先前的肌阵挛或阵挛性癫痫发作或脑电图峰值。毒蕈碱激动剂盐酸匹洛卡平，在非常大的剂量下，诱导轻微的多动和促进强直性癫痫发作，但不影响肌阵挛或阵挛性癫痫发作。其拮抗剂（−）氢溴酸东莨菪碱，轻度降低觉醒和肌阵挛性和阵挛性发作阈值。注射激动剂和拮抗剂（d-管柯碱氯（+）酒石酸尼古丁或（±）盐酸匹洛卡品+(−)东莨菪碱）的混合物对自发行为或癫痫发作的影响很小。这些结果表明，在胆碱能神经传递的控制下，丘脑中线调节癫痫发作和觉醒。烟碱受体和毒蕈碱受体在调节这些功能方面具有相反的作用。
This study determined the effects of injections of different cholinergic agents in the central medial intralaminar nucleus of the thalamus on seizures induced by intravenous injection of pentylenetetrazol. Injections of the cholinesterase inhibitor, neostigmine bromide, induced a stiff, tremulous state and lowered myoclonic, clonic and tonic seizure thresholds. The nicotinic agonist, nicotine tartrate, depressed arousal and facilitated all types of seizure, while its antagonist,d-tubocurarine chloride, heightened arousal and transformed pentylenetetrazol-induced convulsions, with tonic seizures occurring at a very low threshold without preceding myoclonic or clonic seizures or EEG spikes. The muscarinic agonist ( ± )pilocarpine hydrochloride, in very large doses, induced slight hyperactivity and facilitated tonic seizures but did not affect myoclonic or clonic seizures. Its antagonist, ( − )scopolamine hydrobromide, slightly depressed arousal and myoclonic and clonic seizure thresholds. Injections of mixtures of agonists and antagonists (d-tubocurarine chloride ( + ) nicotine tartrate or ( ± )pilocarpine hydrochloride + ( − )scopolamine) had little effect on spontaneous behavior or seizures.These results suggest that the midline thalamus regulates seizures and arousal, under the control of cholinergic neurotransmission. Nicotinic and muscarinic receptors have opposing roles in mediating these functions.